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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4x5h FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4x5h FOLDihydrofolate reductase 1.5.1.3 0.945
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.865
4x5i FOLDihydrofolate reductase 1.5.1.3 0.851
4x5g FOLDihydrofolate reductase 1.5.1.3 0.842
4i13 FOLDihydrofolate reductase 1.5.1.3 0.829
1dyh DZFDihydrofolate reductase 1.5.1.3 0.822
1dyi FOLDihydrofolate reductase 1.5.1.3 0.821
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.815
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.810
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.808
4m6k FOLDihydrofolate reductase 1.5.1.3 0.807
4x5f FOLDihydrofolate reductase 1.5.1.3 0.806
2zza FOLDihydrofolate reductase / 0.805
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.803
2d0k FOLDihydrofolate reductase 1.5.1.3 0.802
3tqb FOLDihydrofolate reductase / 0.802
1drf FOLDihydrofolate reductase 1.5.1.3 0.801
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.797
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.793
4kfj FOLDihydrofolate reductase 1.5.1.3 0.792
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.791
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.791
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.789
4kjj FOLDihydrofolate reductase 1.5.1.3 0.788
4i1n FOLDihydrofolate reductase 1.5.1.3 0.783
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.781
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.779
1dhf FOLDihydrofolate reductase 1.5.1.3 0.772
1tdr MTXDihydrofolate reductase 1.5.1.3 0.768
1hfq MOTDihydrofolate reductase 1.5.1.3 0.766
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.757
4keb FOLDihydrofolate reductase 1.5.1.3 0.755
1jol FFODihydrofolate reductase 1.5.1.3 0.753
1jom FFODihydrofolate reductase 1.5.1.3 0.753
5hi6 MTXDihydrofolate reductase / 0.751
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.750
2drc MTXDihydrofolate reductase 1.5.1.3 0.749
4fhb FOLDihydrofolate reductase 1.5.1.3 0.745
4p66 MTXDihydrofolate reductase / 0.745
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.741
3dau MTXDihydrofolate reductase 1.5.1.3 0.737
1e26 GPBDihydrofolate reductase 1.5.1.3 0.736
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.735
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.734
1hfr MOTDihydrofolate reductase 1.5.1.3 0.733
1dre MTXDihydrofolate reductase 1.5.1.3 0.731
4x5j FOLDihydrofolate reductase 1.5.1.3 0.731
3eig MTXDihydrofolate reductase 1.5.1.3 0.729
1u70 MTXDihydrofolate reductase 1.5.1.3 0.727
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.726
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.726
1ohj COPDihydrofolate reductase 1.5.1.3 0.724
1dhj MTXDihydrofolate reductase 1.5.1.3 0.721
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.721
3drc MTXDihydrofolate reductase 1.5.1.3 0.720
1u72 MTXDihydrofolate reductase 1.5.1.3 0.718
4m6l 21VDihydrofolate reductase 1.5.1.3 0.718
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.716
1re7 FOLDihydrofolate reductase 1.5.1.3 0.714
2dhf DZFDihydrofolate reductase 1.5.1.3 0.714
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.707
1drb MTXDihydrofolate reductase 1.5.1.3 0.706
3tq9 MTXDihydrofolate reductase / 0.706
1df7 MTXDihydrofolate reductase 1.5.1.3 0.704
1hfp MOTDihydrofolate reductase 1.5.1.3 0.704
3dfr MTXDihydrofolate reductase 1.5.1.3 0.703
3och 2MXDihydrofolate reductase 1.5.1.3 0.703
5ccc DDFDihydrofolate reductase 1.5.1.3 0.703
3ghw GHWDihydrofolate reductase 1.5.1.3 0.700
1dhi MTXDihydrofolate reductase 1.5.1.3 0.698
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.698
7dfr FOLDihydrofolate reductase 1.5.1.3 0.697
4dfr MTXDihydrofolate reductase 1.5.1.3 0.696
1dls MTXDihydrofolate reductase 1.5.1.3 0.693
1dyj DDFDihydrofolate reductase 1.5.1.3 0.692
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.692
3ia4 MTXDihydrofolate reductase / 0.688
1ohk COPDihydrofolate reductase 1.5.1.3 0.686
1dra MTXDihydrofolate reductase 1.5.1.3 0.685
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.685
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.680
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.679
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.676
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.674
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.674
4qi9 MTXDihydrofolate reductase / 0.674
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.673
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.672
2bjs ACVIsopenicillin N synthase 1.21.3.1 0.662
3td8 D2RDihydrofolate reductase 1.5.1.3 0.659
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.658
2w3m FOLDihydrofolate reductase 1.5.1.3 0.658
2ahc VNLChorismate pyruvate-lyase / 0.656
4l8u 9AZSerum albumin / 0.656
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.655
4p68 MTXDihydrofolate reductase / 0.655
4a39 GEMUncharacterized protein / 0.654
1ex7 5GPGuanylate kinase 2.7.4.8 0.651
1x28 PGUAspartate aminotransferase 2.6.1.1 0.651
3aej AA5Methionine gamma-lyase / 0.651
5iot UMPFlavin-dependent thymidylate synthase 2.1.1.148 0.651
1odn APVIsopenicillin N synthase 1.21.3.1 0.650
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.650