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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4x5f FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4x5f FOLDihydrofolate reductase 1.5.1.3 1.082
4x5g FOLDihydrofolate reductase 1.5.1.3 0.944
1dyh DZFDihydrofolate reductase 1.5.1.3 0.943
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.940
4kjj FOLDihydrofolate reductase 1.5.1.3 0.940
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.940
1dyi FOLDihydrofolate reductase 1.5.1.3 0.922
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.922
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.921
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.899
4fhb FOLDihydrofolate reductase 1.5.1.3 0.887
7dfr FOLDihydrofolate reductase 1.5.1.3 0.870
1dyj DDFDihydrofolate reductase 1.5.1.3 0.867
1re7 FOLDihydrofolate reductase 1.5.1.3 0.866
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.863
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.854
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.853
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.851
4m6k FOLDihydrofolate reductase 1.5.1.3 0.845
5ccc DDFDihydrofolate reductase 1.5.1.3 0.844
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.841
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.819
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.815
1jom FFODihydrofolate reductase 1.5.1.3 0.812
2zza FOLDihydrofolate reductase / 0.812
4i1n FOLDihydrofolate reductase 1.5.1.3 0.812
4i13 FOLDihydrofolate reductase 1.5.1.3 0.811
1dhf FOLDihydrofolate reductase 1.5.1.3 0.810
1hfr MOTDihydrofolate reductase 1.5.1.3 0.810
4kfj FOLDihydrofolate reductase 1.5.1.3 0.806
4x5h FOLDihydrofolate reductase 1.5.1.3 0.806
5hi6 MTXDihydrofolate reductase / 0.806
3tqb FOLDihydrofolate reductase / 0.805
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.801
1dra MTXDihydrofolate reductase 1.5.1.3 0.795
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.795
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.791
1hfp MOTDihydrofolate reductase 1.5.1.3 0.783
3tq9 MTXDihydrofolate reductase / 0.782
1drf FOLDihydrofolate reductase 1.5.1.3 0.781
1dhj MTXDihydrofolate reductase 1.5.1.3 0.780
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.779
3drc MTXDihydrofolate reductase 1.5.1.3 0.779
1dhi MTXDihydrofolate reductase 1.5.1.3 0.775
1drb MTXDihydrofolate reductase 1.5.1.3 0.772
2drc MTXDihydrofolate reductase 1.5.1.3 0.770
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.769
4keb FOLDihydrofolate reductase 1.5.1.3 0.769
4dfr MTXDihydrofolate reductase 1.5.1.3 0.768
4qi9 MTXDihydrofolate reductase / 0.766
1hfq MOTDihydrofolate reductase 1.5.1.3 0.763
3ghv GHCDihydrofolate reductase 1.5.1.3 0.761
4p66 MTXDihydrofolate reductase / 0.760
2w3m FOLDihydrofolate reductase 1.5.1.3 0.759
1dre MTXDihydrofolate reductase 1.5.1.3 0.755
1jol FFODihydrofolate reductase 1.5.1.3 0.755
3eig MTXDihydrofolate reductase 1.5.1.3 0.753
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.751
4m6l 21VDihydrofolate reductase 1.5.1.3 0.744
1df7 MTXDihydrofolate reductase 1.5.1.3 0.738
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.738
1tdr MTXDihydrofolate reductase 1.5.1.3 0.738
3och 2MXDihydrofolate reductase 1.5.1.3 0.738
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.737
2d0k FOLDihydrofolate reductase 1.5.1.3 0.737
3dau MTXDihydrofolate reductase 1.5.1.3 0.737
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.734
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.730
1u70 MTXDihydrofolate reductase 1.5.1.3 0.729
4p68 MTXDihydrofolate reductase / 0.729
3dfr MTXDihydrofolate reductase 1.5.1.3 0.727
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.726
1ohj COPDihydrofolate reductase 1.5.1.3 0.724
3ghw GHWDihydrofolate reductase 1.5.1.3 0.724
4x5i FOLDihydrofolate reductase 1.5.1.3 0.710
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.705
1dls MTXDihydrofolate reductase 1.5.1.3 0.700
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.696
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.696
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.690
1ddr MTXDihydrofolate reductase 1.5.1.3 0.685
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.684
1dds MTXDihydrofolate reductase 1.5.1.3 0.682
4x5j FOLDihydrofolate reductase 1.5.1.3 0.681
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.680
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.669
2qk8 MTXDihydrofolate reductase / 0.664
3frd DHFDihydrofolate reductase 1.5.1.3 0.662
1u72 MTXDihydrofolate reductase 1.5.1.3 0.659
2dhf DZFDihydrofolate reductase 1.5.1.3 0.658
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.655
3ia4 MTXDihydrofolate reductase / 0.654