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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wzh FMN Dihydroorotate dehydrogenase (fumarate)

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 1.132
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 1.121
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 1.121
3gye FMNDihydroorotate dehydrogenase (fumarate) / 1.101
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.065
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.063
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.063
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.028
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.021
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.012
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.988
3oix FMNDihydroorotate dehydrogenase / 0.918
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.871
1z41 FMNNADPH dehydrogenase / 0.864
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.858
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.849
3l5l FMNXenobiotic reductase / 0.836
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.831
3hf3 FMNChromate reductase / 0.828
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.828
1gwj FMNMorphinone reductase / 0.827
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.809
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.809
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.807
4tmb FMNOld yellow enzyme / 0.797
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.795
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.793
1h63 FMNPentaerythritol tetranitrate reductase / 0.791
5ebu FMNLactate oxidase / 0.782
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.776
3p62 FMNPentaerythritol tetranitrate reductase / 0.775
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.775
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.774
4qai FMNNADPH dehydrogenase / 0.773
4e2b FMNDehydrogenase / 0.772
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.771
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.767
3n19 FNRXenobiotic reductase / 0.767
4yl2 FMNLactate oxidase / 0.757
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.753
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.752
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.751
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.750
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.747
3gka FMNN-ethylmaleimide reductase / 0.745
3p74 FMNPentaerythritol tetranitrate reductase / 0.744
3gr8 FMNNADPH dehydrogenase / 0.734
4utk FNRXenobiotic reductase / 0.733
2abb FMNPentaerythritol tetranitrate reductase / 0.729
2du2 FMNLactate oxidase / 0.725
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.722
3p8i FMNPentaerythritol tetranitrate reductase / 0.721
4m5p FMNNADPH dehydrogenase / 0.721
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.721
4df2 FMNNADPH dehydrogenase / 0.720
3tjl FMNNADPH dehydrogenase / 0.716
3p8j FMNPentaerythritol tetranitrate reductase / 0.713
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.711
1h51 FMNPentaerythritol tetranitrate reductase / 0.709
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.709
3p82 FMNPentaerythritol tetranitrate reductase / 0.707
1h50 FMNPentaerythritol tetranitrate reductase / 0.705
4yco FMNtRNA-dihydrouridine(16) synthase / 0.702
3p67 FMNPentaerythritol tetranitrate reductase / 0.698
1vyr FMNPentaerythritol tetranitrate reductase / 0.697
3p84 FMNPentaerythritol tetranitrate reductase / 0.690
4jic FMNGTN Reductase / 0.689
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.688
3f03 FMNPentaerythritol tetranitrate reductase / 0.688
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.688
4uth FMNXenobiotic reductase / 0.687
4cw5 FMNDfnA / 0.679
4rje FNRLactate oxidase / 0.679
2h8x FMNXenA / 0.672
3hji FADVivid PAS protein VVD / 0.672
3n3b FMNProtein NrdI / 0.671
2vyx FMNDodecin / 0.670
1z48 FMNNADPH dehydrogenase / 0.669
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.667
3atz FMNProstaglandin F2a synthase / 0.667
5a89 FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.667
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.666
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.665
2gjl FMNNitronate monooxygenase 1.13.12.16 0.665
3qe2 FMNNADPH--cytochrome P450 reductase / 0.661
3sw1 FMNSensory box protein / 0.660
4e2d FMNDehydrogenase / 0.659
4hj6 FMNLOV protein / 0.658
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.657
3n14 FMNXenobiotic reductase / 0.657
3zho FMNNAD(P)H dehydrogenase (quinone) / 0.657
5cpm FNRNADH:flavin oxidoreductase / 0.657
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.655
4utm FNRXenobiotic reductase / 0.655
2z9d FMNFMN-dependent NADH-azoreductase / 0.652
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.652
4bmo FMNProtein NrdI / 0.652
1r2j FADFkbI / 0.651
4utl FNRXenobiotic reductase / 0.651
4yus FMNFamily 3 adenylate cyclase / 0.651
5j4e FMNSensory box protein / 0.651
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.650