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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wxg 2BO Serine hydroxymethyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4wxg 2BOSerine hydroxymethyltransferase / 1.162
4wxf PLGSerine hydroxymethyltransferase / 1.026
1dfo PLGSerine hydroxymethyltransferase 2.1.2.1 0.918
2ycn P61Tyrosine phenol-lyase 4.1.99.2 0.718
3aej AA5Methionine gamma-lyase / 0.704
4eb5 PLPCysteine desulfurase IscS 2 / 0.696
4eb7 PLPCysteine desulfurase IscS 2 / 0.687
1wkh PPE[LysW]-aminoadipate semialdehyde transaminase / 0.686
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.678
4d9f DCSD-cysteine desulfhydrase / 0.678
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.676
1arg PPDAspartate aminotransferase 2.6.1.1 0.675
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.674
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.671
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.670
1cq7 PY5Aspartate aminotransferase 2.6.1.1 0.666
4emy PLPAminotransferase class I and II / 0.666
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 0.664
1wkg POI[LysW]-aminoadipate semialdehyde transaminase / 0.663
4d9m 0JODiaminopropionate ammonia-lyase 4.3.1.15 0.662
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.661
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.655
4obu PLPPyridoxal-dependent decarboxylase domain protein / 0.653
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.651
1x28 PGUAspartate aminotransferase 2.6.1.1 0.651