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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wbb ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.013
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.785
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.785
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.748
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.735
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.734
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.730
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.726
5dos ATPAurora kinase A 2.7.11.1 0.726
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.724
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
4o1p ANPRibonuclease L / 0.721
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.716
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.716
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.714
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.713
4n57 ADPAPH(2'')-Id / 0.713
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.712
5drd ATPAurora kinase A 2.7.11.1 0.711
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.710
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.708
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
4qny ANPMitogen activated protein kinase, putative / 0.704
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.704
2pui ADPMethylthioribose kinase 2.7.1.100 0.703
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.703
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.702
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.702
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.702
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.701
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.699
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.698
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.694
5dnr ATPAurora kinase A 2.7.11.1 0.694
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
5eg3 ACPFibroblast growth factor receptor 2 / 0.692
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.691
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.691
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.690
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.690
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
5dt4 ATPAurora kinase A 2.7.11.1 0.689
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.688
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.686
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.686
4dee ADPAurora kinase A 2.7.11.1 0.686
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.686
3t8o ATPRhodopsin kinase / 0.685
4ysj ADPCalmodulin-like domain protein kinase / 0.685
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.684
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.684
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.683
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.683
5dn3 ATPAurora kinase A 2.7.11.1 0.683
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.681
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.680
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.679
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
3rv4 ADPBiotin carboxylase 6.3.4.14 0.677
5iqd GNPBifunctional AAC/APH 2.3.1 0.677
1ol7 ADPAurora kinase A 2.7.11.1 0.676
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.676
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.676
2dwb ANPAurora kinase A 2.7.11.1 0.676
4lv8 ADPRhoptry protein 5 C / 0.676
2olc ADPMethylthioribose kinase 2.7.1.100 0.675
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.675
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.674
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1mq4 ADPAurora kinase A 2.7.11.1 0.673
1ol6 ATPAurora kinase A 2.7.11.1 0.673
5dr2 ATPAurora kinase A 2.7.11.1 0.673
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.672
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.672
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.671
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.670
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.670
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.670
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.669
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.668
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.668
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.668
3c4z ADPRhodopsin kinase / 0.668
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.668
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.667
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.667
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
4xlv ACPInsulin receptor 2.7.10.1 0.667
5ckw ANPUncharacterized protein / 0.667
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.666
2pup ADPMethylthioribose kinase 2.7.1.100 0.665
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.665
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.665
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.665
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.665
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.665
4ork GDPBifunctional AAC/APH 2.3.1 0.665
5iqh GNPBifunctional AAC/APH 2.3.1 0.665
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.664
2pun ACPMethylthioribose kinase 2.7.1.100 0.664
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.664
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.664
5byl GCPBifunctional AAC/APH 2.3.1 0.664
5iqb GNPBifunctional AAC/APH 2.3.1 0.664
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.663
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.663
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.662
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.662
5dt3 ATPAurora kinase A 2.7.11.1 0.662
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.661
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3c50 ADPRhodopsin kinase / 0.660
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.660
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
3nie ANPMitogen-activated protein kinase / 0.658
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
4c3r ACPAurora kinase A 2.7.11.1 0.656
4ceg ADPAurora kinase A 2.7.11.1 0.656
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.656
3c4w ATPRhodopsin kinase / 0.655
3eps ATPIsocitrate dehydrogenase kinase/phosphatase / 0.655
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.655
5ack ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.654
3qc9 ADPRhodopsin kinase / 0.654
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.653
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
5iqa GNPBifunctional AAC/APH 2.3.1 0.652
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.651
1ir3 ANPInsulin receptor 2.7.10.1 0.651
2pul ACPMethylthioribose kinase 2.7.1.100 0.651
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.650
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.650
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.650
4rqv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650