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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4uya AGS Mitogen-activated protein kinase kinase kinase 21 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.832
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.715
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.703
3d5w ADPSerine/threonine-protein kinase PLK / 0.696
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.694
4dca ADPAminoglycoside phosphotransferase / 0.693
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.687
2pml ANPUncharacterized protein / 0.686
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.683
2pbz ATPUncharacterized protein / 0.681
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.679
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.678
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.675
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.673
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.673
4c2w ANPAurora kinase B-A 2.7.11.1 0.673
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
2b8j ADNClass B acid phosphatase 3.1.3.2 0.671
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.671
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.670
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
3b2t M33Fibroblast growth factor receptor 2 / 0.667
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.666
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.666
4xhg ADPUncharacterized protein / 0.666
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.665
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.665
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.664
4dta ADNAPH(2'')-Id / 0.663
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.662
2olc ADPMethylthioribose kinase 2.7.1.100 0.661
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.661
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.660
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.660
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.659
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.657
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.657
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.656
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.656
4blt APCNTPase P4 / 0.656
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.655
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4id7 1G0Activated CDC42 kinase 1 / 0.654
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.653
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.653
3k31 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.653
1i44 ACPInsulin receptor 2.7.10.1 0.652
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.652
3tin ADPTtl protein / 0.652
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.651
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.650