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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4uxq 0LI Fibroblast growth factor receptor 4 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 1.258
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.929
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.896
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.869
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.825
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.817
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.814
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.777
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.759
3iph G11Mitogen-activated protein kinase 14 / 0.748
3dt1 P40Mitogen-activated protein kinase 14 / 0.744
3e92 G6AMitogen-activated protein kinase 14 / 0.743
3d7z GK5Mitogen-activated protein kinase 14 / 0.733
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.729
3gfe P37Mitogen-activated protein kinase 14 / 0.725
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.717
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.717
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.699
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.694
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.690
3dtw A96Vascular endothelial growth factor receptor 2 2.7.10.1 0.690
2zb1 GK4Mitogen-activated protein kinase 14 / 0.689
2p4i MR9Angiopoietin-1 receptor 2.7.10.1 0.688
4kiq 1RAMitogen-activated protein kinase 14 / 0.686
3gi3 B10Mitogen-activated protein kinase 14 / 0.683
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
3bv3 P39Mitogen-activated protein kinase 14 / 0.677
3fkl FKLMitogen-activated protein kinase 14 / 0.676
2rg6 287Mitogen-activated protein kinase 14 / 0.673
3itz P66Mitogen-activated protein kinase 14 / 0.673
4kip 1R9Mitogen-activated protein kinase 14 / 0.673
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.672
3rin I2OMitogen-activated protein kinase 14 / 0.672
3hng 8STVascular endothelial growth factor receptor 1 2.7.10.1 0.671
4agc AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.671
3mvl 38PMitogen-activated protein kinase 14 / 0.667
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3efl 706Vascular endothelial growth factor receptor 2 2.7.10.1 0.664
3bx5 304Mitogen-activated protein kinase 14 / 0.660
3u8w 09JMitogen-activated protein kinase 14 / 0.656
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.655
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.655
2osc MUHAngiopoietin-1 receptor 2.7.10.1 0.654
2yiw YIWMitogen-activated protein kinase 14 / 0.652