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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4uun NAI L-lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4uun NAIL-lactate dehydrogenase / 1.029
1bdm NAXMalate dehydrogenase / 0.756
1b8v NADMalate dehydrogenase / 0.741
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.698
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.697
4jji NADAlcohol dehydrogenase class-3 / 0.693
4l0q NADAlcohol dehydrogenase class-3 / 0.693
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.687
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.685
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.684
1bmd NADMalate dehydrogenase / 0.682
4weq NAPNAD-dependent dehydrogenase / 0.681
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.680
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.673
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.672
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.672
1uxj NADMalate dehydrogenase / 0.671
4cpd NADAlcohol dehydrogenase / 0.671
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.668
2dc1 NADProbable L-aspartate dehydrogenase / 0.667
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.666
2d8a NADL-threonine 3-dehydrogenase / 0.666
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.665
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.659
1uxk NADMalate dehydrogenase / 0.659
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
5a1t NAIL-lactate dehydrogenase / 0.657
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.656
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.656
4gl4 NAIAlcohol dehydrogenase class-3 / 0.656
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.655
4lcj NADC-terminal-binding protein 2 / 0.655
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.654
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.652
1o6z NADMalate dehydrogenase / 0.651
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.651
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.651