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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4usr FAD Monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4usr FADMonooxygenase / 1.230
4usq FADPyridine nucleotide-disulfide oxidoreductase / 0.925
4c5o FADPutative monooxygenase / 0.898
3ish FADThioredoxin reductase 1.8.1.9 0.770
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.759
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.759
1h81 FADPolyamine oxidase 1.5.3.14 0.756
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.750
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.745
4k2x FADPolyketide oxygenase/hydroxylase / 0.739
4b69 FADL-ornithine N(5)-monooxygenase / 0.729
4ap3 FADSteroid monooxygenase / 0.727
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.725
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.725
1zk7 FADMercuric reductase 1.16.1.1 0.723
3ada NADSubunit alpha of sarocosine oxidase / 0.719
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.718
4jq9 FADDihydrolipoyl dehydrogenase / 0.717
1rsg FADPolyamine oxidase FMS1 / 0.714
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.714
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.713
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.713
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.713
4j2w FADKynurenine 3-monooxygenase / 0.709
4nzh FADL-ornithine N(5)-monooxygenase / 0.709
2iid FADL-amino-acid oxidase 1.4.3.2 0.708
4j33 FADKynurenine 3-monooxygenase / 0.707
1ojt FADDihydrolipoyl dehydrogenase / 0.706
4mo2 FADUDP-galactopyranose mutase / 0.704
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.703
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.700
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.699
3nlc FADUncharacterized protein / 0.699
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.699
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.699
1y56 ATPUncharacterized protein / 0.698
4aos FADSteroid monooxygenase / 0.698
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
1ijh FADCholesterol oxidase 1.1.3.6 0.696
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.696
2x8g FADThioredoxin glutathione reductase / 0.694
4j57 FADThioredoxin reductase 2 1.8.1.9 0.694
4k5r FADOxygenase / 0.694
4gdp FADPolyamine oxidase FMS1 / 0.693
3ict FADCoenzyme A disulfide reductase / 0.692
4x4j FADPutative oxygenase / 0.692
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.690
4gus FADLysine-specific histone demethylase 1B 1 0.690
4tm3 FADKtzI / 0.689
4b65 FADL-ornithine N(5)-monooxygenase / 0.688
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.688
4qi4 FADCellobiose dehydrogenase / 0.688
4tlz FADKtzI / 0.688
1pdh FASp-hydroxybenzoate hydroxylase / 0.687
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.687
1k0j FADp-hydroxybenzoate hydroxylase / 0.686
2cul FADGidA-related protein / 0.686
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.686
4b68 FADL-ornithine N(5)-monooxygenase / 0.686
5buk FADFADH2-dependent halogenase / 0.686
1h83 FADPolyamine oxidase 1.5.3.14 0.685
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.684
4gcm FADThioredoxin reductase 1.8.1.9 0.683
2yg4 FADPutrescine oxidase / 0.682
3fpz AHZThiamine thiazole synthase / 0.682
3k30 ADPHistamine dehydrogenase / 0.682
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.682
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.681
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.681
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.681
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.680
2yg7 FADPutrescine oxidase / 0.680
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.679
2eq8 FADDihydrolipoyl dehydrogenase / 0.678
4ap1 FADSteroid monooxygenase / 0.678
1c0k FADD-amino-acid oxidase 1.4.3.3 0.677
1cbo FADCholesterol oxidase 1.1.3.6 0.677
1k0l FADp-hydroxybenzoate hydroxylase / 0.677
3sz0 FADSulfide-quinone reductase / 0.677
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.677
1c0l FADD-amino-acid oxidase 1.4.3.3 0.676
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
2xvf FADPutative flavin-containing monooxygenase / 0.676
3lsm SFDPyranose 2-oxidase / 0.676
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.675
2q0l FADThioredoxin reductase 1.8.1.9 0.675
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.675
3atq FDAConserved Archaeal protein / 0.675
3b6d FAECholesterol oxidase 1.1.3.6 0.675
4cnk FADL-amino acid oxidase / 0.675
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.674
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.674
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.674
3s55 NADPutative short-chain dehydrogenase/reductase / 0.674
4opg FDAConserved Archaeal protein / 0.674
4tm4 FDAKtzI / 0.674
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.673
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.672
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
2igo FADPyranose 2-oxidase / 0.671
4at0 FADPossible succinate dehydrogenase / 0.671
4guu FA9Lysine-specific histone demethylase 1B 1 0.671
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.671
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.670
4guv FADTetX family tetracycline inactivation enzyme / 0.670
2iw5 FADLysine-specific histone demethylase 1A 1 0.669
3mj4 FADUDP-galactopyranose mutase / 0.669
4opl FDAConserved Archaeal protein / 0.669
4xbf FADLysine-specific histone demethylase 1A 1 0.669
2gr0 FADFerredoxin reductase / 0.668
2yg5 FADPutrescine oxidase / 0.668
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.668
3bg7 FADPyranose 2-oxidase / 0.668
4gur FADLysine-specific histone demethylase 1B 1 0.668
4j36 FADKynurenine 3-monooxygenase / 0.668
4tm1 FDAKtzI / 0.668
5l3d FADLysine-specific histone demethylase 1A 1 0.668
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.667
2jb1 FADL-amino acid oxidase / 0.667
2xve FADPutative flavin-containing monooxygenase / 0.667
2yg3 FADPutrescine oxidase / 0.667
3atr FDAConserved Archaeal protein / 0.667
3kve FADL-amino-acid oxidase / 0.667
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.666
1get FADGlutathione reductase 1.8.1.7 0.666
3jsk AHZThiamine thiazole synthase / 0.666
4cnj FADL-amino acid oxidase / 0.666
4fwf FADLysine-specific histone demethylase 1B 1 0.666
5cku FADL-ornithine N(5)-monooxygenase / 0.666
3rp8 FADFAD-dependent urate hydroxylase / 0.665
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.665
4yac NAIC alpha-dehydrogenase / 0.665
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.664
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.664
4j56 FADThioredoxin reductase 2 1.8.1.9 0.664
1xpq FADPolyamine oxidase FMS1 / 0.663
2y48 FADLysine-specific histone demethylase 1A 1 0.663
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.663
4j34 FADKynurenine 3-monooxygenase / 0.663
4la1 FADThioredoxin glutathione reductase / 0.663
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.663
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.662
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.662
3gwd FADCyclohexanone monooxygenase / 0.662
2eq7 NADDihydrolipoyl dehydrogenase / 0.661
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.661
2r9z FADGlutathione amide reductase / 0.661
3f8p NADNADH oxidase/thioredoxin reductase / 0.661
3lsi FADPyranose 2-oxidase / 0.661
2dw4 FADLysine-specific histone demethylase 1A 1 0.660
2eq6 FADDihydrolipoyl dehydrogenase / 0.660
4rsl FADFructosyl peptide oxidase / 0.660
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.659
2b9w FADPutative aminooxidase / 0.659
2eq9 FADDihydrolipoyl dehydrogenase / 0.659
2gew FADCholesterol oxidase 1.1.3.6 0.659
2xyo FADTetX family tetracycline inactivation enzyme / 0.659
2yg6 FADPutrescine oxidase / 0.659
3kpk FADSulfide-quinone reductase / 0.659
1z6l FADPolyamine oxidase FMS1 / 0.658
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.658
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.658
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.658
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.657
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.657
3ukl FADUDP-galactopyranose mutase / 0.657
4d7e FADPutative lysine-N-oxygenase / 0.657
4icy FADPgaE / 0.657
4jnq FDAThioredoxin reductase / 0.657
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.657
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.656
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.656
3fbs FADOxidoreductase / 0.656
4gut FADLysine-specific histone demethylase 1B 1 0.656
4yag NAIC alpha-dehydrogenase / 0.656
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.655
3ukk FDAUDP-galactopyranose mutase / 0.655
4b66 FADL-ornithine N(5)-monooxygenase / 0.655
4i58 FADCyclohexylamine Oxidase / 0.655
4opi FDAConserved Archaeal protein / 0.655
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.654
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.654
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.654
4bk2 FADProbable salicylate monooxygenase / 0.654
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.654
4fwe FADLysine-specific histone demethylase 1B 1 0.654
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.654
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.654
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
2qa1 FADPgaE / 0.653
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.653
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.653
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.653
3kkj FADRenalase / 0.652
4b63 FADL-ornithine N(5)-monooxygenase / 0.652
4bjz FADProbable salicylate monooxygenase / 0.652
4hb9 FADUncharacterized protein / 0.652
1feb FADTrypanothione reductase 1.8.1.12 0.651
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.651
2rgj FADFlavin-containing monooxygenase / 0.651
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.651
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.651
4tlx FDAKtzI / 0.651
1cl0 FADThioredoxin reductase 1.8.1.9 0.650
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.650
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.650
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.650