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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4uak ADP Serine/threonine-protein kinase MRCK beta 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 1.018
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.866
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.854
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.854
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.854
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.849
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.844
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.840
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.837
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.825
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.822
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.821
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.820
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.820
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.819
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.819
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.819
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.816
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.815
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.811
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.810
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.808
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.808
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.805
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.802
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.800
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.800
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.799
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.798
1mq4 ADPAurora kinase A 2.7.11.1 0.797
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.797
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.793
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.791
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.790
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.790
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.790
4ysj ADPCalmodulin-like domain protein kinase / 0.789
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.788
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.787
4utd ACPAurora kinase A 2.7.11.1 0.787
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.786
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.784
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.783
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.782
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.782
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.777
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.776
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.776
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.775
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.769
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.768
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.768
2pui ADPMethylthioribose kinase 2.7.1.100 0.766
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.763
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.762
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.761
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.761
5dn3 ATPAurora kinase A 2.7.11.1 0.761
5iqb GNPBifunctional AAC/APH 2.3.1 0.761
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.760
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.759
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.757
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.756
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.756
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.754
3bu5 ATPInsulin receptor 2.7.10.1 0.754
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.751
2vqd AP2Biotin carboxylase 6.3.4.14 0.751
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.751
4ork GDPBifunctional AAC/APH 2.3.1 0.751
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.750
3c4z ADPRhodopsin kinase / 0.748
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.745
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.745
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.744
4dee ADPAurora kinase A 2.7.11.1 0.744
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.743
2j9g ADPBiotin carboxylase 6.3.4.14 0.742
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.742
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.741
3rv4 ADPBiotin carboxylase 6.3.4.14 0.741
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.741
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.739
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.738
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.738
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.737
4fu0 ADPD-alanine--D-alanine ligase / 0.736
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.736
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.735
5dr2 ATPAurora kinase A 2.7.11.1 0.735
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.733
5ce3 ADPProtein kinase YopO / 0.733
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.732
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.731
3c50 ADPRhodopsin kinase / 0.731
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.730
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.730
2olc ADPMethylthioribose kinase 2.7.1.100 0.729
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.728
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.727
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
5dos ATPAurora kinase A 2.7.11.1 0.726
5dt4 ATPAurora kinase A 2.7.11.1 0.726
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.724
2pyw ADPMethylthioribose kinase 2.7.1.100 0.723
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.723
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
4qny ANPMitogen activated protein kinase, putative / 0.721
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.720
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.720
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.720
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.719
3g8c ADPBiotin carboxylase 6.3.4.14 0.718
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.718
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.717
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.717
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.717
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.717
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.716
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.715
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.715
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.715
2pup ADPMethylthioribose kinase 2.7.1.100 0.714
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.713
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.713
4o1p ANPRibonuclease L / 0.713
4gyi ADPUncharacterized protein / 0.712
1m0w ANPGlutathione synthetase 6.3.2.3 0.711
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.711
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.710
3qc9 ADPRhodopsin kinase / 0.709
4ffl ADPUncharacterized protein / 0.708
4ceg ADPAurora kinase A 2.7.11.1 0.706
5dt3 ATPAurora kinase A 2.7.11.1 0.706
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.705
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.705
2pml ANPUncharacterized protein / 0.704
4n57 ADPAPH(2'')-Id / 0.704
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.703
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.702
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.702
1ol5 ADPAurora kinase A 2.7.11.1 0.701
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.701
3cly ACPFibroblast growth factor receptor 2 / 0.700
4ffm ADPUncharacterized protein / 0.700
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.697
1ol7 ADPAurora kinase A 2.7.11.1 0.696
2dwb ANPAurora kinase A 2.7.11.1 0.696
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.696
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.695
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.695
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.694
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.694
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.693
5iqf GDPBifunctional AAC/APH 2.3.1 0.693
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.691
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.691
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.691
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.690
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.690
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.689
3tdv GDPGentamicin resistance protein / 0.689
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.689
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.689
3tdw GDPGentamicin resistance protein / 0.688
5iqh GNPBifunctional AAC/APH 2.3.1 0.688
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.686
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.685
4bn1 ADPAurora kinase A 2.7.11.1 0.685
4xlv ACPInsulin receptor 2.7.10.1 0.685
1u54 ACPActivated CDC42 kinase 1 / 0.684
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.684
5byl GCPBifunctional AAC/APH 2.3.1 0.684
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.680
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.680
4fhp UTPTerminal uridylyltransferase cid1 / 0.679
3q5i ANPProtein kinase, putative / 0.678
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.678
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.677
4o4f ATPKinase / 0.677
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.676
3wnz ADPAlanine--anticapsin ligase / 0.676
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.676
5drd ATPAurora kinase A 2.7.11.1 0.676
1ol6 ATPAurora kinase A 2.7.11.1 0.675
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.675
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.674
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.674
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.673
2pun ACPMethylthioribose kinase 2.7.1.100 0.673
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.673
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.673
5dnr ATPAurora kinase A 2.7.11.1 0.673
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.672
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.671
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.671
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.670
5iqe GNPBifunctional AAC/APH 2.3.1 0.670
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.669
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.669
1pjk ANPCasein kinase II subunit alpha 2.7.11.1 0.668
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.668
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.668
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.668
1cm8 ANPMitogen-activated protein kinase 12 / 0.667
1dv2 ATPBiotin carboxylase 6.3.4.14 0.667
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.667
5ckw ANPUncharacterized protein / 0.667
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.666
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.665
1g9r UPFLgtC / 0.664
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.664
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.664
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.664
4ffr ATPUncharacterized protein / 0.664
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
3tw6 ADPPyruvate carboxylase / 0.663
4o4e ATPKinase / 0.663
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.662
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.662
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.662
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.662
2pul ACPMethylthioribose kinase 2.7.1.100 0.661
5iqi GNPBifunctional AAC/APH 2.3.1 0.661
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.660
2pz5 ACPFibroblast growth factor receptor 2 / 0.660
2fsn ADPArchaeal actin homolog / 0.659
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.659
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.659
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.659
4q5h ANPProtein kinase OspG 2.7 0.658
5iqa GNPBifunctional AAC/APH 2.3.1 0.658
3wo1 ADPAlanine--anticapsin ligase / 0.657
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
1kp2 ATPArgininosuccinate synthase 6.3.4.5 0.656
2j9g ANPBiotin carboxylase 6.3.4.14 0.655
2yaa ATPDeath-associated protein kinase 2 / 0.655
3nie ANPMitogen-activated protein kinase / 0.655
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
4c3r ACPAurora kinase A 2.7.11.1 0.655
5iqd GNPBifunctional AAC/APH 2.3.1 0.655
5l8j ADPAurora kinase A 2.7.11.1 0.655
1ss9 UPFLgtC / 0.654
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.654
2p0a ANPSynapsin-3 / 0.653
3t8o ATPRhodopsin kinase / 0.652
4ix5 ANPUncharacterized protein / 0.652
2qen ADPWalker-Type ATPase / 0.651
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.651
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.651
4bwa N0BPyrrolysine--tRNA ligase / 0.651
1ir3 ANPInsulin receptor 2.7.10.1 0.650
2ydo ADNAdenosine receptor A2a / 0.650
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4bgb ADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases / 0.650
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.650