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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u8o FDA UDP-galactopyranose mutase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4u8o FDAUDP-galactopyranose mutase / 1.376
4u8n FDAUDP-galactopyranose mutase / 1.370
4gde FDAUDP-galactopyranose mutase / 1.367
4u8m FDAUDP-galactopyranose mutase / 1.351
3utg FDAUDP-galactopyranose mutase / 1.339
4wx1 FDAUDP-galactopyranose mutase / 1.331
4u8l FDAUDP-galactopyranose mutase / 1.325
4u8p FDAUDP-galactopyranose mutase / 1.318
4u8k FDAUDP-galactopyranose mutase / 1.316
3uth FDAUDP-galactopyranose mutase / 1.312
3utf FDAUDP-galactopyranose mutase / 1.306
4u8i FDAUDP-galactopyranose mutase / 1.293
4u8j FDAUDP-galactopyranose mutase / 1.255
4dsh FDAUncharacterized protein / 1.167
3ukl FADUDP-galactopyranose mutase / 1.118
4dsg FADUncharacterized protein / 1.073
3ukf FDAUDP-galactopyranose mutase / 1.061
3ukk FADUDP-galactopyranose mutase / 0.947
3ukk FDAUDP-galactopyranose mutase / 0.919
3ute FADUDP-galactopyranose mutase / 0.899
3uka FADUDP-galactopyranose mutase / 0.891
2jb2 FADL-amino acid oxidase / 0.851
2jb1 FADL-amino acid oxidase / 0.838
5hhf FDAUDP-galactopyranose mutase / 0.827
1tdn FADL-amino-acid oxidase 1.4.3.2 0.826
3kve FADL-amino-acid oxidase / 0.822
1reo FADL-amino-acid oxidase 1.4.3.2 0.821
1tdo FADL-amino-acid oxidase 1.4.3.2 0.811
1f8s FADL-amino-acid oxidase 1.4.3.2 0.808
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.803
1f8r FADL-amino-acid oxidase 1.4.3.2 0.801
2iid FADL-amino-acid oxidase 1.4.3.2 0.801
2iw5 FADLysine-specific histone demethylase 1A 1 0.800
1tdk FADL-amino-acid oxidase 1.4.3.2 0.796
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.795
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.794
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.792
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.792
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.792
1yy5 FADPolyamine oxidase FMS1 / 0.786
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.785
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.784
3we0 FADLysine 2-monooxygenase / 0.784
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.783
2y48 FADLysine-specific histone demethylase 1A 1 0.782
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.781
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.780
3r9u FADThioredoxin reductase / 0.780
2dw4 FADLysine-specific histone demethylase 1A 1 0.779
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.779
5l3d FADLysine-specific histone demethylase 1A 1 0.779
4gcm FADThioredoxin reductase 1.8.1.9 0.778
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.777
2jae FADL-amino acid oxidase / 0.777
4rsl FADFructosyl peptide oxidase / 0.777
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.775
2b9x FADPutative aminooxidase / 0.775
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.774
2q7v FADThioredoxin reductase / 0.771
1rsg FADPolyamine oxidase FMS1 / 0.769
2h94 FADLysine-specific histone demethylase 1A 1 0.767
3he3 FADUDP-galactopyranose mutase / 0.766
3ish FADThioredoxin reductase 1.8.1.9 0.765
1nhr FADNADH peroxidase 1.11.1.1 0.763
1nhs FADNADH peroxidase 1.11.1.1 0.763
1z6l FADPolyamine oxidase FMS1 / 0.763
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.762
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.761
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.760
3f8d FADNADH oxidase/thioredoxin reductase / 0.759
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.755
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.755
2yg3 FADPutrescine oxidase / 0.754
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.754
3ka7 FADPutative oxidoreductase / 0.754
4xbf FADLysine-specific histone demethylase 1A 1 0.754
4i58 FADCyclohexylamine Oxidase / 0.753
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.752
3gsi FADDimethylglycine oxidase 1.5.3.10 0.750
1nhq FADNADH peroxidase 1.11.1.1 0.748
2e1m FADL-glutamate oxidase / 0.746
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.746
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.745
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.745
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.745
2gvc FADThiol-specific monooxygenase 1.14.13 0.743
2yg5 FADPutrescine oxidase / 0.743
3cgb FADCoenzyme A disulfide reductase / 0.743
3cge FADCoenzyme A disulfide reductase / 0.741
4gus FADLysine-specific histone demethylase 1B 1 0.741
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.739
4mo2 FDAUDP-galactopyranose mutase / 0.739
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.737
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.737
4fwf FADLysine-specific histone demethylase 1B 1 0.737
1tde FADThioredoxin reductase 1.8.1.9 0.736
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.734
2xlr FADPutative flavin-containing monooxygenase / 0.734
3hdy FADUDP-galactopyranose mutase / 0.734
1xpq FADPolyamine oxidase FMS1 / 0.732
2yg4 FADPutrescine oxidase / 0.732
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.731
3cgc FADCoenzyme A disulfide reductase / 0.731
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.731
3hdy FDAUDP-galactopyranose mutase / 0.730
4hsu FADLysine-specific histone demethylase 1B 1 0.730
2b9w FADPutative aminooxidase / 0.728
2b9y FADPutative aminooxidase / 0.728
4gdc FADUDP-galactopyranose mutase / 0.728
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.727
2qa1 FADPgaE / 0.726
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.726
3vqr FADPutative oxidoreductase / 0.726
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.726
4tm3 FADKtzI / 0.726
4ysh FADGlycine oxidase / 0.726
3lov FADProtoporphyrinogen oxidase / 0.723
2npx FADNADH peroxidase 1.11.1.1 0.722
1h81 FADPolyamine oxidase 1.5.3.14 0.720
4jnq FDAThioredoxin reductase / 0.720
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.719
3cnd FADPolyamine oxidase FMS1 / 0.718
3cty FADProbable thioredoxin reductase / 0.718
1trb FADThioredoxin reductase 1.8.1.9 0.717
3cnt FADPolyamine oxidase FMS1 / 0.717
4fwj FADLysine-specific histone demethylase 1B 1 0.717
4eqx FADCoenzyme A disulfide reductase / 0.716
4gut FADLysine-specific histone demethylase 1B 1 0.716
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.715
2a87 FADThioredoxin reductase 1.8.1.9 0.714
3mj4 FADUDP-galactopyranose mutase / 0.714
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.713
4gdp FADPolyamine oxidase FMS1 / 0.713
1h83 FADPolyamine oxidase 1.5.3.14 0.711
3bi2 FADPolyamine oxidase FMS1 / 0.711
4b64 FADL-ornithine N(5)-monooxygenase / 0.710
4gur FADLysine-specific histone demethylase 1B 1 0.710
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.709
2bac FADPutative aminooxidase / 0.708
3cgd FADCoenzyme A disulfide reductase / 0.708
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.708
3rha FDAPutrescine oxidase / 0.708
4eqw FADCoenzyme A disulfide reductase / 0.707
4k2x FADPolyketide oxygenase/hydroxylase / 0.707
3rp8 FADFAD-dependent urate hydroxylase / 0.706
4em3 FADCoenzyme A disulfide reductase / 0.706
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.705
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.704
4x4j FADPutative oxygenase / 0.704
2qa2 FADPolyketide oxygenase CabE / 0.702
2uxx FAJLysine-specific histone demethylase 1A 1 0.702
3zdn FADMonoamine oxidase N 1.4.3.4 0.702
4fwe FADLysine-specific histone demethylase 1B 1 0.701
1yqz FADCoenzyme A disulfide reductase / 0.700
4em4 FADCoenzyme A disulfide reductase / 0.700
4up3 FADThioredoxin reductase / 0.700
5hxw FADL-amino acid deaminase / 0.700
5buk FADFADH2-dependent halogenase / 0.699
2ba9 FADPutative aminooxidase / 0.698
2xdo FADTetX family tetracycline inactivation enzyme / 0.698
2yg6 FADPutrescine oxidase / 0.698
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.697
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
1tdf FADThioredoxin reductase 1.8.1.9 0.696
1f3p FADFerredoxin reductase / 0.694
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.694
1zx9 FADMercuric reductase 1.16.1.1 0.694
2hko FADLysine-specific histone demethylase 1A 1 0.694
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.693
3kpf FADPolyamine oxidase 1.5.3.14 0.693
4guu FA9Lysine-specific histone demethylase 1B 1 0.693
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.693
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.691
4ntd FADThioredoxin reductase / 0.691
3ict FADCoenzyme A disulfide reductase / 0.690
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.690
2wet FADTryptophan 5-halogenase / 0.689
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.689
1ger FADGlutathione reductase 1.8.1.7 0.688
2q0k FADThioredoxin reductase 1.8.1.9 0.688
3cn8 FADPolyamine oxidase FMS1 / 0.688
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.688
4mih FADPyranose 2-oxidase 1.1.3.10 0.688
3bg7 FADPyranose 2-oxidase / 0.687
1ryi FADGlycine oxidase 1.4.3.19 0.686
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
3pl8 FADPyranose 2-oxidase / 0.686
4j36 FADKynurenine 3-monooxygenase / 0.686
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.685
3t14 FADSulfide-quinone reductase / 0.685
4gdd FADUDP-galactopyranose mutase / 0.685
2du8 FADD-amino-acid oxidase 1.4.3.3 0.684
3lsi FADPyranose 2-oxidase / 0.684
1c0k FADD-amino-acid oxidase 1.4.3.3 0.683
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.683
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
4rph FADUDP-galactopyranose mutase 5.4.99.9 0.683
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
1zk7 FADMercuric reductase 1.16.1.1 0.681
3t2z FADSulfide-quinone reductase / 0.681
4tm4 FDAKtzI / 0.681
2gqw FADFerredoxin reductase / 0.680
2gr0 FADFerredoxin reductase / 0.680
2q0l FADThioredoxin reductase 1.8.1.9 0.680
3k4c FADPyranose 2-oxidase / 0.680
2yvf FADFerredoxin reductase / 0.679
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.678
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.678
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.677
2igo FADPyranose 2-oxidase / 0.677
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.677
2eq6 FADDihydrolipoyl dehydrogenase / 0.676
2gv8 FADThiol-specific monooxygenase 1.14.13 0.676
3lad FADDihydrolipoyl dehydrogenase / 0.676
4ccq FADThioredoxin reductase / 0.676
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.676
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.676
1ng4 FADGlycine oxidase 1.4.3.19 0.675
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.675
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.675
4opt FDAConserved Archaeal protein / 0.675
1c0l FADD-amino-acid oxidase 1.4.3.3 0.674
2ywl FADThioredoxin reductase related protein / 0.674
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.674
4bk3 FADProbable salicylate monooxygenase / 0.674
2vq7 FADPutative flavin-containing monooxygenase / 0.673
4b1b FADThioredoxin reductase 1.8.1.9 0.673
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.673
1gal FADGlucose oxidase 1.1.3.4 0.672
4opl FDAConserved Archaeal protein / 0.672
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.672
2bab FADPutative aminooxidase / 0.671
3jsk AHZThiamine thiazole synthase / 0.671
4opi FDAConserved Archaeal protein / 0.671
2vqb FADPutative flavin-containing monooxygenase / 0.670
2xvf FADPutative flavin-containing monooxygenase / 0.670
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.669
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.669
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.669
4x9m FADUncharacterized protein MG039 homolog / 0.669
5dbj FADFADH2-dependent halogenase PltA / 0.669
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.668
2vvl FADMonoamine oxidase N 1.4.3.4 0.668
2wes FADTryptophan 5-halogenase / 0.668
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.668
3znp FADD-amino-acid oxidase 1.4.3.3 0.668
3fmw FADOxygenase / 0.667
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.667
4eqs FADCoenzyme A disulfide reductase / 0.667
4rhe FMNFlavin prenyltransferase UbiX / 0.667
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.667
4eqr FADCoenzyme A disulfide reductase / 0.666
4guv FADTetX family tetracycline inactivation enzyme / 0.666
4bjz FADProbable salicylate monooxygenase / 0.665
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.665
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.665
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.665
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.664
2cvj FADThioredoxin reductase related protein / 0.664
3gwd FADCyclohexanone monooxygenase / 0.664
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.664
4ech FADPolyamine oxidase FMS1 / 0.664
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.664
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.663
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.663
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.663
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.663
1f8w FADNADH peroxidase 1.11.1.1 0.662
2ign FADPyranose 2-oxidase / 0.662
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.662
1y56 ATPUncharacterized protein / 0.661
3ad9 FADSubunit beta of sarcosine oxidase / 0.661
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.661
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
4nzh FADL-ornithine N(5)-monooxygenase / 0.661
1nhp FADNADH peroxidase 1.11.1.1 0.660
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.660
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.660
4icy FADPgaE / 0.660
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.660
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.660
4opc FDAConserved Archaeal protein / 0.660
2jkc FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.659
2v6o FADThioredoxin glutathione reductase / 0.659
2xlp FADPutative flavin-containing monooxygenase / 0.659
2cdu FADNADH oxidase / 0.658
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
2gr1 FADFerredoxin reductase / 0.658
2yg7 FADPutrescine oxidase / 0.658
4wct FADFructosyl amine:oxygen oxidoreductase / 0.658
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
2xls FADPutative flavin-containing monooxygenase / 0.657
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.657
3lsm SFDPyranose 2-oxidase / 0.657
3qj4 FADRenalase / 0.657
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.657
4mok FADPyranose 2-oxidase / 0.657
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.657
3f6s FMNFlavodoxin / 0.656
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.656
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.656
5j60 FADThioredoxin reductase / 0.656
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.655
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
4j31 FADKynurenine 3-monooxygenase / 0.654
4z26 FADPutative GMC-type oxidoreductase R135 1 0.654
1feb FADTrypanothione reductase 1.8.1.12 0.653
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.653
3axb FADPutative oxidoreductase / 0.653
3f8p NADNADH oxidase/thioredoxin reductase / 0.653
3kpk FADSulfide-quinone reductase / 0.652
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
4jq9 FADDihydrolipoyl dehydrogenase / 0.652
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.651
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.651
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.651
4oxx FMNCindoxin / 0.651
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.651
1b4v FADCholesterol oxidase 1.1.3.6 0.650
1b8s FADCholesterol oxidase 1.1.3.6 0.650
3dme FADPutative conserved exported protein / 0.650
4a65 FADThioredoxin reductase / 0.650
4j2w FADKynurenine 3-monooxygenase / 0.650