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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u0m GTP Cyclic GMP-AMP synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4u0m GTPCyclic GMP-AMP synthase / 1.119
4u03 GTPCyclic GMP-AMP synthase / 0.901
4xj3 GTPCyclic GMP-AMP synthase / 0.854
4txz G2PCyclic GMP-AMP synthase / 0.831
4xj4 3ATCyclic GMP-AMP synthase / 0.816
2q66 ATPPoly(A) polymerase 2.7.7.19 0.722
3er9 3ATPoly(A) polymerase catalytic subunit 2.7.7.19 0.722
3hiy UTPUncharacterized protein / 0.706
4fvq ATPTyrosine-protein kinase JAK2 / 0.686
1cjv DADAdenylate cyclase type 2 / 0.680
1cjv DADAdenylate cyclase type 5 / 0.680
1r89 CTPCCA-adding enzyme 2.7.7.72 0.673
2ikf UTPPoly(A) polymerase, putative / 0.673
1r8c UTPCCA-adding enzyme 2.7.7.72 0.671
4fhp UTPTerminal uridylyltransferase cid1 / 0.671
4at8 ATPInterleukin enhancer-binding factor 2 / 0.669
3dys 5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A / 0.666
5itz GTPTubulin alpha-1B chain / 0.666
5ce3 ADPProtein kinase YopO / 0.657
4fh5 UTPTerminal uridylyltransferase cid1 / 0.652
4ptf DCPDNA polymerase epsilon catalytic subunit A 2.7.7.7 0.652
4fhy 3ATTerminal uridylyltransferase cid1 / 0.651
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.651
1ndc TYDNucleoside diphosphate kinase, cytosolic 2.7.4.6 0.650
3hav ATPAminoglycoside phosphotransferase / 0.650