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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u0i 0LI Mast/stem cell growth factor receptor Kit 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 1.219
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.929
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.896
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.861
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.846
3ugc 046Tyrosine-protein kinase JAK2 / 0.845
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.823
3dtw A96Vascular endothelial growth factor receptor 2 2.7.10.1 0.819
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.819
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.818
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.801
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.777
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.759
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.739
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.738
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.733
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.730
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.728
3hng 8STVascular endothelial growth factor receptor 1 2.7.10.1 0.725
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.716
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.716
3gcs BAXMitogen-activated protein kinase 14 / 0.710
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.704
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.702
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.687
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.683
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.682
4kip 1R9Mitogen-activated protein kinase 14 / 0.675
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.670
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.666
3e92 G6AMitogen-activated protein kinase 14 / 0.666
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.665
3bv2 P38Mitogen-activated protein kinase 14 / 0.658
1u3r 338Estrogen receptor beta / 0.652
2p2i 608Vascular endothelial growth factor receptor 2 2.7.10.1 0.652
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.650