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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4to5 TTP Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4to5 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.321
4tnq TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.182
4tnx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.014
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.007
4to6 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.968
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.967
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.935
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.907
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.906
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.906
4tnz DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.877
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.845
4qfx DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.834
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.825
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.743
1dlj UGAUDP-glucose 6-dehydrogenase / 0.682
3m1f ATPActin, alpha skeletal muscle / 0.666
3uf6 CODLmo1369 protein / 0.662
3hl4 CDCCholine-phosphate cytidylyltransferase A / 0.658
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.656
4xr9 TMPCalS8 / 0.654