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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4to3 DCP Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4to3 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.109
4to2 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.070
4to0 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.057
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.050
4to1 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.037
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.032
4qg1 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.024
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.021
4to4 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.017
4to5 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.964
4qfz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.935
4qg0 DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.924
4mz7 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.897
4to6 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.877
4rxp DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.857
4tny DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.831
4rxr DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.826
4rxs TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.798
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.776
4rxq DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.759
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.660
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.656