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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4to2 DGT Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4to2 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.211
4to0 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.072
4to3 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.070
4to1 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.053
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.035
4qg1 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.034
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.021
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.015
4to5 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.999
4to4 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.990
4qg0 DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.935
4to6 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.923
4qfz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.914
4tny DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.912
4mz7 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.889
4rxp DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.841
4rxr DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.822
4rxs TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.814
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.803
4rxq DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.766
4zwe DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.700
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.682
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.650
3kai 4FIPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5.2.1.8 0.650