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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4to0 DTP Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.301
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.156
4tnq TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.149
4tnx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.117
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.105
4qfx DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.100
4tnz DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.063
4to6 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.059
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.058
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.024
4to5 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.007
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.990
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.985
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.956
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.738
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.698
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.697
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.680
4xvq GNPGTPase HRas / 0.670
3s3t ATPUniversal stress protein / 0.668
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.667
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.666
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.665
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.665
4dxj 0M9Farnesyl pyrophosphate synthase / 0.664
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.662
3x1z GNPRas-related protein Rap-1b / 0.659
4idn GNPAtlastin-1 3.6.5 0.656
4a28 ADPKinesin-like protein KIF11 / 0.655
1nmq 160Caspase-3 3.4.22.56 0.654
1u0h GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.654
3zia ATPATP synthase subunit alpha, mitochondrial / 0.654
1t44 ATPActin, alpha skeletal muscle / 0.652
2gil GTPRas-related protein Rab-6A / 0.651
3ldw IPEFarnesyl pyrophosphate synthase, putative / 0.651
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.650
3krf IPEGeranyl diphosphate synthase large subunit / 0.650