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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tnx DGT Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4tnx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.346
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.225
4tnq TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.200
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.176
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.161
4tnz DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.155
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.117
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.077
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.057
4to6 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.052
4qfx DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.026
4to5 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.014
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.998
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.907
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.755
4tle AGSCircadian clock protein kinase KaiC 2.7.11.1 0.667
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.665
3m0e ATPTranscriptional regulator (NtrC family) / 0.659
2py7 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.656
4to4 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.654
1vg8 GNPRas-related protein Rab-7a / 0.652
3ump ATPATP-dependent 6-phosphofructokinase isozyme 2 2.7.1.11 0.652
2cl6 CAGGTPase HRas / 0.651