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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4s32 ANP Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.832
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.779
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.771
3tei ANPMitogen-activated protein kinase 1 2.7.11.24 0.769
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.734
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.714
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.695
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.691
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
1cm8 ANPMitogen-activated protein kinase 12 / 0.676
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.674
4xlv ACPInsulin receptor 2.7.10.1 0.674
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.673
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.673
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.671
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.669
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.666
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.664
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.663
1nve NADPentafunctional AROM polypeptide / 0.660
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.659
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.657
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.657
2h2a DNDProbable nicotinate-nucleotide adenylyltransferase / 0.656
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.654
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.653
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.652
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
1i6l TYMTryptophan--tRNA ligase 6.1.1.2 0.651
2olc ADPMethylthioribose kinase 2.7.1.100 0.651
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.650