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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rls NAI L-lactate dehydrogenase A chain 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.964
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.765
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.740
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.739
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.730
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.717
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.715
2x0i NAIMalate dehydrogenase / 0.714
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.714
1ib6 NADMalate dehydrogenase / 0.713
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.710
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.709
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.709
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.708
1x7d NADPutative ornithine cyclodeaminase / 0.708
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.707
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.706
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.706
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.706
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.705
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.705
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.705
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.704
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.703
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.699
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.698
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.696
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.694
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.694
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.693
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.691
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.691
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.690
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.690
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.689
1u7h NADPutative ornithine cyclodeaminase / 0.688
3wsw NADL-lactate dehydrogenase / 0.688
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.688
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.687
4jk3 NADUncharacterized protein / 0.687
1sow NADL-lactate dehydrogenase 1.1.1.27 0.686
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.685
2a92 NAIL-lactate dehydrogenase / 0.684
2x0r NADMalate dehydrogenase / 0.680
5a1t NAIL-lactate dehydrogenase / 0.679
1pzh NADLactate dehydrogenase / 0.678
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.677
1ie3 NADMalate dehydrogenase / 0.677
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.675
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.674
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.673
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.671
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.670
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.670
2ome NADC-terminal-binding protein 2 / 0.670
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
4j49 NADUncharacterized protein / 0.667
4cpd NADAlcohol dehydrogenase / 0.666
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.666
1bmd NADMalate dehydrogenase / 0.665
4j49 NAIUncharacterized protein / 0.665
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.664
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.664
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.663
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.662
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.662
2dph NADFormaldehyde dismutase / 0.660
4nzh FADL-ornithine N(5)-monooxygenase / 0.660
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.659
2o4c NADErythronate-4-phosphate dehydrogenase / 0.659
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
3jv7 NADSecondary alcohol dehydrogenase / 0.658
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.658
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.657
4tvb NADHomospermidine synthase 2.5.1.44 0.657
1hku NADC-terminal-binding protein 1 1.1.1 0.656
4ros APRMalate dehydrogenase / 0.656
2voj NADAlanine dehydrogenase 1.4.1.1 0.655
1emd NADMalate dehydrogenase / 0.654
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.653
4c4o NADSADH / 0.653
1ek5 NADUDP-glucose 4-epimerase / 0.651
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.651
2dfv NADL-threonine 3-dehydrogenase / 0.650
3geg NADShort-chain dehydrogenase/reductase SDR / 0.650