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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4riy ANP Receptor tyrosine-protein kinase erbB-3 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 1.046
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.787
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.711
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.706
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.690
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.689
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.684
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.679
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.668
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.666
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.666
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.660
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.657
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.655
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.654
4prv ADPDNA gyrase subunit B / 0.653
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.651