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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4r7i STI Macrophage colony-stimulating factor 1 receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 1.197
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.921
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.882
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.869
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.856
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.839
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.772
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.737
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 0.726
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.722
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.716
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.716
3bv2 P38Mitogen-activated protein kinase 14 / 0.715
3bv3 P39Mitogen-activated protein kinase 14 / 0.715
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.705
4aa4 QC0Mitogen-activated protein kinase 14 / 0.697
3ocg OCGMitogen-activated protein kinase 14 / 0.682
3d83 GK6Mitogen-activated protein kinase 14 / 0.680
3gfe P37Mitogen-activated protein kinase 14 / 0.673
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.672
4kiq 1RAMitogen-activated protein kinase 14 / 0.669
3mvm 39PMitogen-activated protein kinase 14 / 0.663
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.662
3o8p BMUMitogen-activated protein kinase 14 / 0.659
4aa0 AA0Mitogen-activated protein kinase 14 / 0.659
3lfa 1N1Mitogen-activated protein kinase 14 / 0.657
4eh6 0ONMitogen-activated protein kinase 14 / 0.653