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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qi4 FAD Cellobiose dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4qi4 FADCellobiose dehydrogenase / 1.254
4qi5 FADCellobiose dehydrogenase / 1.167
4qi7 FADCellobiose dehydrogenase / 0.951
3gyj FADCholesterol oxidase 1.1.3.6 0.950
1mxt FAECholesterol oxidase 1.1.3.6 0.942
1n4w FADCholesterol oxidase 1.1.3.6 0.942
2gew FADCholesterol oxidase 1.1.3.6 0.936
4xxg FADCholesterol oxidase 1.1.3.6 0.928
1n1p FADCholesterol oxidase 1.1.3.6 0.927
4rek FADCholesterol oxidase 1.1.3.6 0.927
1b8s FADCholesterol oxidase 1.1.3.6 0.924
1n4u FAECholesterol oxidase 1.1.3.6 0.922
4xwr FADCholesterol oxidase 1.1.3.6 0.922
3gyi FADCholesterol oxidase 1.1.3.6 0.921
4u2t FADCholesterol oxidase 1.1.3.6 0.920
1ijh FADCholesterol oxidase 1.1.3.6 0.911
1n4v FADCholesterol oxidase 1.1.3.6 0.907
3b6d FAECholesterol oxidase 1.1.3.6 0.906
3cox FADCholesterol oxidase 1.1.3.6 0.896
1cbo FADCholesterol oxidase 1.1.3.6 0.892
4u2s FDACholesterol oxidase 1.1.3.6 0.891
3cnj FADCholesterol oxidase 1.1.3.6 0.890
1b4v FADCholesterol oxidase 1.1.3.6 0.886
1gpe FADGlucose oxidase 1.1.3.4 0.875
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.873
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.863
1cf3 FADGlucose oxidase 1.1.3.4 0.855
3qvr FADGlucose oxidase 1.1.3.4 0.845
4u2l SFDCholesterol oxidase 1.1.3.6 0.841
1cc2 FADCholesterol oxidase 1.1.3.6 0.831
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.831
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.826
3t37 FADPyridoxine 4-oxidase / 0.825
3qvp FADGlucose oxidase 1.1.3.4 0.806
4ynt FDAGlucose oxidase, putative / 0.801
1gal FADGlucose oxidase 1.1.3.4 0.796
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.791
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.788
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.784
4z26 FADPutative GMC-type oxidoreductase R135 1 0.782
4z24 FADPutative GMC-type oxidoreductase R135 1 0.780
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.770
5hsa FASAlcohol oxidase 1 1.1.3.13 0.770
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.759
2q0k FADThioredoxin reductase 1.8.1.9 0.758
2gqf FADUncharacterized protein HI_0933 / 0.757
3lsh FADPyranose 2-oxidase / 0.748
4yry FADGlutamate synthase, beta subunit / 0.747
4gcm FADThioredoxin reductase 1.8.1.9 0.746
4at0 FADPossible succinate dehydrogenase / 0.745
1h81 FADPolyamine oxidase 1.5.3.14 0.743
2q0l FADThioredoxin reductase 1.8.1.9 0.743
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.741
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.739
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.738
4mih FADPyranose 2-oxidase 1.1.3.10 0.736
4b66 FADL-ornithine N(5)-monooxygenase / 0.734
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.733
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.733
3jsk AHZThiamine thiazole synthase / 0.731
3kpf FADPolyamine oxidase 1.5.3.14 0.730
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.729
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.729
4fwe FADLysine-specific histone demethylase 1B 1 0.729
5j60 FADThioredoxin reductase / 0.728
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.727
4gur FADLysine-specific histone demethylase 1B 1 0.725
4gut FADLysine-specific histone demethylase 1B 1 0.725
2e1m FADL-glutamate oxidase / 0.724
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.724
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.722
3lsi FADPyranose 2-oxidase / 0.722
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.721
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.720
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.719
2uxx FAJLysine-specific histone demethylase 1A 1 0.719
4fwf FADLysine-specific histone demethylase 1B 1 0.718
4i58 FADCyclohexylamine Oxidase / 0.718
2yg7 FADPutrescine oxidase / 0.717
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.715
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.715
1h83 FADPolyamine oxidase 1.5.3.14 0.713
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.713
3nlc FADUncharacterized protein / 0.711
3q9t FAYUncharacterized protein / 0.711
1fea FADTrypanothione reductase 1.8.1.12 0.710
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.710
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
3v76 FDAUncharacterized protein / 0.710
4guu FA9Lysine-specific histone demethylase 1B 1 0.710
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.709
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.708
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.708
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.708
1trb FADThioredoxin reductase 1.8.1.9 0.706
3pl8 FADPyranose 2-oxidase / 0.706
1f8s FADL-amino-acid oxidase 1.4.3.2 0.704
2eq8 FADDihydrolipoyl dehydrogenase / 0.704
2yg3 FADPutrescine oxidase / 0.704
2yg4 FADPutrescine oxidase / 0.704
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.703
1kif FADD-amino-acid oxidase 1.4.3.3 0.703
2q7v FADThioredoxin reductase / 0.703
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.703
5br7 FADUDP-galactopyranose mutase / 0.703
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
4b67 FADL-ornithine N(5)-monooxygenase / 0.702
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.702
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.701
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.700
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.700
4hsu FADLysine-specific histone demethylase 1B 1 0.700
1zk7 FADMercuric reductase 1.16.1.1 0.698
2vvl FADMonoamine oxidase N 1.4.3.4 0.698
3k4c FADPyranose 2-oxidase / 0.698
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.698
4ccq FADThioredoxin reductase / 0.698
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.698
4tm4 FDAKtzI / 0.698
2dw4 FADLysine-specific histone demethylase 1A 1 0.697
2ign FADPyranose 2-oxidase / 0.697
1tde FADThioredoxin reductase 1.8.1.9 0.696
2yg6 FADPutrescine oxidase / 0.696
3cnd FADPolyamine oxidase FMS1 / 0.696
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.695
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.695
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.694
2jb1 FADL-amino acid oxidase / 0.694
3ish FADThioredoxin reductase 1.8.1.9 0.694
4nte FADDepH / 0.694
4x9n FADUncharacterized protein MG039 homolog / 0.694
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.692
3icr FADCoenzyme A disulfide reductase / 0.692
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.692
4opg FDAConserved Archaeal protein / 0.692
4xbf FADLysine-specific histone demethylase 1A 1 0.692
1tdf FADThioredoxin reductase 1.8.1.9 0.691
4up3 FADThioredoxin reductase / 0.691
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.691
5buk FADFADH2-dependent halogenase / 0.691
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.690
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.690
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.690
4tlx FDAKtzI / 0.690
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.689
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.689
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.689
3cgb FADCoenzyme A disulfide reductase / 0.688
4usr FADMonooxygenase / 0.688
3fpz AHZThiamine thiazole synthase / 0.687
4jn9 FADDepH / 0.687
4mo2 FDAUDP-galactopyranose mutase / 0.687
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.686
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.686
4x9m FADUncharacterized protein MG039 homolog / 0.686
1yy5 FADPolyamine oxidase FMS1 / 0.685
2jae FADL-amino acid oxidase / 0.685
3cty FADProbable thioredoxin reductase / 0.685
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.685
2h94 FADLysine-specific histone demethylase 1A 1 0.684
3cgc FADCoenzyme A disulfide reductase / 0.684
3fbs FADOxidoreductase / 0.684
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.684
3t14 FADSulfide-quinone reductase / 0.683
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.683
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.682
2eq7 NADDihydrolipoyl dehydrogenase / 0.682
3cnt FADPolyamine oxidase FMS1 / 0.682
3ict FADCoenzyme A disulfide reductase / 0.682
2y48 FADLysine-specific histone demethylase 1A 1 0.681
3fg2 FADPutative rubredoxin reductase / 0.681
3kkj FADRenalase / 0.681
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.681
4ntd FADThioredoxin reductase / 0.681
2gqw FADFerredoxin reductase / 0.680
2npx FADNADH peroxidase 1.11.1.1 0.680
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.680
3rha FDAPutrescine oxidase / 0.680
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.680
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.680
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.680
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.680
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.679
3atq FDAConserved Archaeal protein / 0.679
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.679
2r9z FADGlutathione amide reductase / 0.678
4cnk FADL-amino acid oxidase / 0.678
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.676
2b9y FADPutative aminooxidase / 0.676
3urh FADDihydrolipoyl dehydrogenase / 0.676
4c3y FAD3-ketosteroid dehydrogenase / 0.675
1ges FADGlutathione reductase 1.8.1.7 0.674
1nhr FADNADH peroxidase 1.11.1.1 0.674
1rsg FADPolyamine oxidase FMS1 / 0.674
2gv8 FADThiol-specific monooxygenase 1.14.13 0.674
3ad9 NADSubunit alpha of sarocosine oxidase / 0.674
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.674
4a65 FADThioredoxin reductase / 0.674
4la1 FADThioredoxin glutathione reductase / 0.674
2eq6 FADDihydrolipoyl dehydrogenase / 0.673
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.673
4cbq FADThioredoxin reductase / 0.673
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.672
3hdy FDAUDP-galactopyranose mutase / 0.672
4opi FDAConserved Archaeal protein / 0.672
4opt FDAConserved Archaeal protein / 0.670
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.669
3ada NADSubunit alpha of sarocosine oxidase / 0.669
4hb9 FADUncharacterized protein / 0.669
1cl0 FADThioredoxin reductase 1.8.1.9 0.668
2wes FADTryptophan 5-halogenase / 0.668
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.668
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.667
2jb2 FADL-amino acid oxidase / 0.667
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.667
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.667
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
1tyt FADTrypanothione reductase 1.8.1.12 0.666
2cul FADGidA-related protein / 0.666
2xlr FADPutative flavin-containing monooxygenase / 0.666
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.666
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.665
2vqb FADPutative flavin-containing monooxygenase / 0.665
3cgd FADCoenzyme A disulfide reductase / 0.665
3ute FADUDP-galactopyranose mutase / 0.665
4gdp FADPolyamine oxidase FMS1 / 0.665
4gus FADLysine-specific histone demethylase 1B 1 0.665
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.664
2bab FADPutative aminooxidase / 0.664
3f8d FADNADH oxidase/thioredoxin reductase / 0.664
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.664
4mo2 FADUDP-galactopyranose mutase / 0.664
2tpr FADTrypanothione reductase 1.8.1.12 0.663
4aos FADSteroid monooxygenase / 0.663
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.662
2iw5 FADLysine-specific histone demethylase 1A 1 0.662
4a99 FADTetX family tetracycline inactivation enzyme / 0.662
4cnj FADL-amino acid oxidase / 0.662
4eep FMNPhototropin-2 2.7.11.1 0.662
2igo FADPyranose 2-oxidase / 0.661
2iid FADL-amino-acid oxidase 1.4.3.2 0.660
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.660
4a5l FADThioredoxin reductase / 0.660
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
1qo8 FADFumarate reductase flavoprotein subunit / 0.659
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.659
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.659
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
2x8h FADThioredoxin glutathione reductase / 0.659
2yg5 FADPutrescine oxidase / 0.659
4c04 SFGProtein arginine N-methyltransferase 6 / 0.659
4ccr FADThioredoxin reductase / 0.659
5jdz SAHMethyl transferase / 0.659
1geu FADGlutathione reductase 1.8.1.7 0.658
2cvj FADThioredoxin reductase related protein / 0.658
3lad FADDihydrolipoyl dehydrogenase / 0.658
4b68 FADL-ornithine N(5)-monooxygenase / 0.658
4jnq FDAThioredoxin reductase / 0.658
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.658
1ng4 FADGlycine oxidase 1.4.3.19 0.657
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
3atr FDAConserved Archaeal protein / 0.656
4hnb FMNLOV protein / 0.656
4j57 FADThioredoxin reductase 2 1.8.1.9 0.656
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.656
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.655
2rab FADGlutathione amide reductase / 0.655
3cge FADCoenzyme A disulfide reductase / 0.655
3syi FADSulfide-quinone reductase / 0.655
4dsh FDAUncharacterized protein / 0.655
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.655
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.654
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.654
4opc FDAConserved Archaeal protein / 0.654
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.653
2p35 SAHTrans-aconitate 2-methyltransferase / 0.653
3lov FADProtoporphyrinogen oxidase / 0.653
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.653
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.653
7mht SAHModification methylase HhaI 2.1.1.37 0.653
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
2b9w FADPutative aminooxidase / 0.652
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.652
4hj4 FMNLOV protein / 0.652
4u8m FDAUDP-galactopyranose mutase / 0.652
2xvf FADPutative flavin-containing monooxygenase / 0.651
3qj4 FADRenalase / 0.651
3zdn FADMonoamine oxidase N 1.4.3.4 0.651
4yac NAIC alpha-dehydrogenase / 0.651
1nw6 SFGModification methylase RsrI 2.1.1.72 0.650
2eq7 FADDihydrolipoyl dehydrogenase / 0.650
3bi5 FADPolyamine oxidase FMS1 / 0.650
3kve FADL-amino-acid oxidase / 0.650
3ukf FDAUDP-galactopyranose mutase / 0.650
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.650
4c3x FAD3-ketosteroid dehydrogenase / 0.650