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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qel TZD Benzoylformate decarboxylase 4.1.1.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4qel TZDBenzoylformate decarboxylase 4.1.1.7 1.125
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 1.120
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 1.119
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 1.118
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 1.117
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 1.115
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 1.114
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 1.110
4jub TPPBenzoylformate decarboxylase 4.1.1.7 1.106
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 1.103
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 1.091
4juf TPPBenzoylformate decarboxylase 4.1.1.7 1.080
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 1.067
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 1.060
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 1.057
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 1.053
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 1.050
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 1.033
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 1.020
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 1.020
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 1.002
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.998
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.997
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.995
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.994
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.975
4cok TPPPyruvate decarboxylase / 0.898
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.862
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.845
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.841
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.820
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.816
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.796
5c4i TPPOxalate oxidoreductase subunit alpha / 0.793
5c4i TPPOxalate oxidoreductase subunit beta / 0.793
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.782
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.778
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.776
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.775
2pan TDPGlyoxylate carboligase 4.1.1.47 0.772
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.771
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.770
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.768
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.767
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.767
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.767
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.766
1y9d TPPPyruvate oxidase 1.2.3.3 0.766
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.766
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.765
3d7k D7KBenzaldehyde lyase / 0.760
1kek HTLPyruvate synthase / 0.759
1pox TPPPyruvate oxidase 1.2.3.3 0.754
3iae D7KBenzaldehyde lyase / 0.753
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.752
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.752
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.746
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.746
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.746
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.744
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.741
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.740
1pow TPPPyruvate oxidase 1.2.3.3 0.739
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.739
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.739
2ezt TDMPyruvate oxidase 1.2.3.3 0.730
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.726
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.718
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.718
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.716
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.715
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.715
3ahi HTLProbable phosphoketolase / 0.714
1ngs TPPTransketolase 1 2.2.1.1 0.713
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.709
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.709
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.709
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.709
5exd TPPOxalate oxidoreductase subunit alpha / 0.709
5exd TPPOxalate oxidoreductase subunit beta / 0.709
2ez9 TDKPyruvate oxidase 1.2.3.3 0.708
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.708
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.708
1ay0 TPPTransketolase 1 2.2.1.1 0.706
2r8o T5XTransketolase 1 / 0.706
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.700
5ahk TPPAcetolactate synthase II, large subunit / 0.700
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.699
3m34 TPPTransketolase / 0.699
2uz1 TPPBenzaldehyde lyase / 0.698
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.696
3ahe THDProbable phosphoketolase / 0.696
3rim TPPTransketolase 2.2.1.1 0.688
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.686
1tkb N1TTransketolase 1 2.2.1.1 0.686
2ag0 TPPBenzaldehyde lyase / 0.685
3upt TPPTransketolase / 0.683
4c7x TPPTransketolase / 0.683
3m6l TPPTransketolase / 0.681
3iaf TPPBenzaldehyde lyase / 0.679
2r5n TPPTransketolase 1 / 0.676
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.676
1trk TPPTransketolase 1 2.2.1.1 0.673
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.673
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.673
1gpu THDTransketolase 1 2.2.1.1 0.672
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.670
1tkc M6TTransketolase 1 2.2.1.1 0.669
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.668
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.667
2r8p T6FTransketolase 1 / 0.666
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.666
2c42 TPPPyruvate synthase / 0.665
3m7i TPPTransketolase / 0.663
2cls GTPRho-related GTP-binding protein Rho6 / 0.659
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.658
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.658
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.657
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.657
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.657
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.656
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.655
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.655
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.651