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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4q5h ANP Protein kinase OspG 2.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4q5h ANPProtein kinase OspG 2.7 0.895
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.771
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.749
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.744
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.740
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.738
4dee ADPAurora kinase A 2.7.11.1 0.734
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.725
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.720
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.718
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.717
3c50 ADPRhodopsin kinase / 0.714
1mq4 ADPAurora kinase A 2.7.11.1 0.713
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.711
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.711
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.709
2olc ADPMethylthioribose kinase 2.7.1.100 0.707
1ol5 ADPAurora kinase A 2.7.11.1 0.706
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.705
2pun ACPMethylthioribose kinase 2.7.1.100 0.703
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.702
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.700
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.699
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.698
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.697
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.696
2pyw ADPMethylthioribose kinase 2.7.1.100 0.695
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.694
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.694
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.691
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.690
2pul ACPMethylthioribose kinase 2.7.1.100 0.689
4o4f ATPKinase / 0.688
1u54 ACPActivated CDC42 kinase 1 / 0.686
5dn3 ATPAurora kinase A 2.7.11.1 0.685
4c3r ACPAurora kinase A 2.7.11.1 0.684
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.683
2pui ADPMethylthioribose kinase 2.7.1.100 0.682
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.682
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.679
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.679
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.679
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.679
2pup ADPMethylthioribose kinase 2.7.1.100 0.678
4ceg ADPAurora kinase A 2.7.11.1 0.678
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.678
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.677
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.677
4qny ANPMitogen activated protein kinase, putative / 0.676
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.675
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.674
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.673
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.673
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.673
3c4z ADPRhodopsin kinase / 0.672
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.672
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.672
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.672
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.671
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.670
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.669
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.669
5dr2 ATPAurora kinase A 2.7.11.1 0.669
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.669
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.668
4o4e ATPKinase / 0.668
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.668
5dt3 ATPAurora kinase A 2.7.11.1 0.668
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.667
4dt8 ADNAPH(2'')-Id / 0.666
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.666
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4c3p ACPAurora kinase A 2.7.11.1 0.665
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.665
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.665
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.665
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.664
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.664
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.664
5dos ATPAurora kinase A 2.7.11.1 0.663
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.662
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.662
2pml ANPUncharacterized protein / 0.662
3cly ACPFibroblast growth factor receptor 2 / 0.661
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.661
2wtk ANPSTE20-related kinase adapter protein alpha / 0.660
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.659
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.659
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.659
4n57 ADPAPH(2'')-Id / 0.659
5dnr ATPAurora kinase A 2.7.11.1 0.659
3bu5 ATPInsulin receptor 2.7.10.1 0.658
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.658
1cm8 ANPMitogen-activated protein kinase 12 / 0.657
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.656
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.656
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.656
4ix5 ANPUncharacterized protein / 0.656
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.654
2dwb ANPAurora kinase A 2.7.11.1 0.653
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.653
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.653
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.653
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.653
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.652
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.652
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.652
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.651
4o1p ANPRibonuclease L / 0.651
5l8k ADPAurora kinase A 2.7.11.1 0.651
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.650
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.650
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.650