Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pxm EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4pxm ESTEstrogen receptor / 1.161
5dxg ESTEstrogen receptor / 1.136
3uud ESTEstrogen receptor / 1.130
2yja ESTEstrogen receptor / 1.122
1gwr ESTEstrogen receptor / 1.086
3l03 4OHEstrogen receptor / 1.084
5hyr ESTEstrogen receptor / 1.068
2qgt EEDEstrogen receptor / 1.066
3q95 ESLEstrogen receptor / 1.061
5dx3 ESTEstrogen receptor / 1.030
2b1z 17MEstrogen receptor / 1.020
2j7x ESTEstrogen receptor beta / 0.998
3oll ESTEstrogen receptor beta / 0.995
2ocf ESTEstrogen receptor / 0.954
2yat EEUEstrogen receptor / 0.954
2g5o DRQEstrogen receptor / 0.890
1g50 ESTEstrogen receptor / 0.873
2q70 DC8Estrogen receptor / 0.779
4j26 ESTEstrogen receptor beta / 0.733
2pip DHTAndrogen receptor / 0.722
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.715
3s79 ASDAromatase 1.14.14.14 0.714
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.713
2pog WSTEstrogen receptor / 0.713
1lhu ESTSex hormone-binding globulin / 0.712
1x7e 244Estrogen receptor / 0.712
2pio DHTAndrogen receptor / 0.710
2aa5 STRMineralocorticoid receptor / 0.708
2pnu ENMAndrogen receptor / 0.707
1p8d CO1Oxysterols receptor LXR-beta / 0.705
3ols ESTEstrogen receptor beta / 0.705
4pp6 STLEstrogen receptor / 0.701
1t7r DHTAndrogen receptor / 0.700
4j24 ESTEstrogen receptor beta / 0.699
4oez DHTAndrogen receptor / 0.699
2j7y E3OEstrogen receptor beta / 0.695
1lhw ESMSex hormone-binding globulin / 0.694
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.693
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.691
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.691
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.690
2pix DHTAndrogen receptor / 0.689
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.689
4at2 ASDPossible succinate dehydrogenase / 0.688
3gki CLRNiemann-Pick C1 protein / 0.685
1yy4 4NAEstrogen receptor beta / 0.684
1aqu ESTEstrogen sulfotransferase, testis isoform 2.8.2.4 0.683
4bqu CLRJapanin / 0.682
2w8y 486Progesterone receptor / 0.675
2ao6 R18Androgen receptor / 0.674
1fdt ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.672
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.671
4y8w STRSteroid 21-hydroxylase / 0.670
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.668
4ofu DHTAndrogen receptor / 0.668
1xq3 R18Androgen receptor / 0.663
4e5f 0N7Polymerase acidic protein / 0.663
5epo TUD7-alpha-hydroxysteroid deydrogenase / 0.663
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.662
4a2j AS0Progesterone receptor / 0.662
1lho AOMSex hormone-binding globulin / 0.661
3m8c EQUSteroid Delta-isomerase 5.3.3.1 0.661
4hlw TESAndrogen receptor / 0.661
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.658
2qe4 JJ3Estrogen receptor / 0.654
3w5r LOAVitamin D3 receptor / 0.651
1lhn AONSex hormone-binding globulin / 0.650
1y9r 1CAMineralocorticoid receptor / 0.650
3i68 J4ZDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.650
4j6b PLOCytochrome P450 monooxygenase / 0.650