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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pt3 NDP Aldehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4pt3 NDPAldehyde dehydrogenase / 1.179
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.776
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.773
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.768
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.766
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.761
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.731
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.728
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.725
4pxl NADAldehyde dehydrogenase3 / 0.708
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.701
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.697
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.696
4pt0 NADAldehyde dehydrogenase / 0.692
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.684
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.670
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.666
5eyu NADBetaine-aldehyde dehydrogenase / 0.660
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.659
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.658
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.655
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.655