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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4psg NOH Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4psg NOHThymidylate synthase / 1.065
4irr UMPThymidylate synthase / 0.867
5by6 UMPThymidylate synthase / 0.855
4e5o UMPThymidylate synthase 2.1.1.45 0.818
4ein NOHThymidylate synthase 2.1.1.45 0.796
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.774
4isk UMPThymidylate synthase / 0.771
4dq1 UMPThymidylate synthase / 0.769
1f28 UMPThymidylate synthase 2.1.1.45 0.764
4eb4 UMPThymidylate synthase 2.1.1.45 0.762
1nja DCMThymidylate synthase / 0.760
1bid UMPThymidylate synthase / 0.749
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.745
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.745
1bp6 UMPThymidylate synthase / 0.744
2fto TMPThymidylate synthase / 0.742
4fox UMPThymidylate synthase ThyA / 0.734
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.733
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.730
2vet UMPThymidylate synthase / 0.726
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.723
1tsy UMPThymidylate synthase / 0.714
1njc DCMThymidylate synthase / 0.708
1vza UMPThymidylate synthase / 0.706
1tsv UMPThymidylate synthase / 0.697
1vzb UMPThymidylate synthase / 0.695
1jmh UMPThymidylate synthase / 0.692
2tdm UMPThymidylate synthase / 0.689
1njb UMPThymidylate synthase / 0.685
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.680
1jmi UMPThymidylate synthase / 0.680
1bp0 UMPThymidylate synthase / 0.679
1tsx UMPThymidylate synthase / 0.677
2tsr UMPThymidylate synthase 2.1.1.45 0.677
1jmf UMPThymidylate synthase / 0.676
2g86 UMPThymidylate synthase / 0.676
3hb8 UMPThymidylate synthase 2.1.1.45 0.672
4fwf FADLysine-specific histone demethylase 1B 1 0.671
3oab DSTGeranyl diphosphate synthase large subunit / 0.670
3koy Z97D-ornithine 4,5-aminomutase subunit beta / 0.665
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.659
1tys TMPThymidylate synthase / 0.659
4iqq UMPThymidylate synthase / 0.656
2zev B71Geranylgeranyl pyrophosphate synthase / 0.655
3u9e COALmo1369 protein / 0.653
1bpj UMPThymidylate synthase / 0.652
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.652