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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ph9 IBP Prostaglandin G/H synthase 2 1.14.99.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ph9 IBPProstaglandin G/H synthase 2 1.14.99.1 1.063
3n8z FLPProstaglandin G/H synthase 1 1.14.99.1 0.815
2ayl FLPProstaglandin G/H synthase 1 1.14.99.1 0.812
1eqh FLPProstaglandin G/H synthase 1 1.14.99.1 0.808
1eqg IBPProstaglandin G/H synthase 1 1.14.99.1 0.796
1ht8 34CProstaglandin G/H synthase 1 1.14.99.1 0.782
1q4g BFLProstaglandin G/H synthase 1 1.14.99.1 0.781
1ht5 FL2Prostaglandin G/H synthase 1 1.14.99.1 0.762
4fm5 DF0Prostaglandin G/H synthase 2 1.14.99.1 0.731
3q7d NPXProstaglandin G/H synthase 2 1.14.99.1 0.719
3pgh FLPProstaglandin G/H synthase 2 1.14.99.1 0.691
3ln0 52BProstaglandin G/H synthase 2 1.14.99.1 0.687
3ntg D72Prostaglandin G/H synthase 2 1.14.99.1 0.671
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.667
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.665
1njd UMPThymidylate synthase / 0.663
1drt PCVClavaminate synthase 1 1.14.11.21 0.661
1q6n P90Tyrosine-protein phosphatase non-receptor type 1 3.1.3.48 0.660
4ubs DIFPentalenic acid synthase 1.14.15.11 0.660
4yau 2AMNADPH--cytochrome P450 reductase / 0.658
3n8w FLPProstaglandin G/H synthase 1 1.14.99.1 0.655
3zp4 TSAChorismate mutase AroH 5.4.99.5 0.655
3n6m GTPGenome polyprotein / 0.651
3fvu IACKynurenine--oxoglutarate transaminase 1 2.6.1.7 0.650
4y7c NAPNADPH--cytochrome P450 reductase / 0.650