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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4p5a FAD Flavin-dependent thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4p5a FADFlavin-dependent thymidylate synthase / 1.261
5ios FADFlavin-dependent thymidylate synthase 2.1.1.148 1.010
1o29 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.965
4p5b FADFlavin-dependent thymidylate synthase / 0.929
3n0b FADFlavin-dependent thymidylate synthase 2.1.1.148 0.925
3g4a FADFlavin-dependent thymidylate synthase 2.1.1.148 0.911
3n0c FADFlavin-dependent thymidylate synthase 2.1.1.148 0.903
2af6 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.858
4gte FADFlavin-dependent thymidylate synthase 2.1.1.148 0.855
4gtl FADFlavin-dependent thymidylate synthase 2.1.1.148 0.815
2gq2 NAPFlavin-dependent thymidylate synthase 2.1.1.148 0.741
3ah5 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.733
3gwc FADFlavin-dependent thymidylate synthase 2.1.1.148 0.726
1uda UFGUDP-glucose 4-epimerase 5.1.3.2 0.684
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.678
4kar FADFlavin-dependent thymidylate synthase 2.1.1.148 0.675
1kq4 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.674
2c2a ADPSensor histidine kinase / 0.662
2gn4 UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.662
3sl2 ATPSensor histidine kinase WalK / 0.660
4a39 GEMUncharacterized protein / 0.659
4prx ADPDNA gyrase subunit B / 0.659
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.656
1a9y UPGUDP-glucose 4-epimerase 5.1.3.2 0.651
4jl8 ADPAdenylate kinase / 0.651
4mkh AP5Adenylate kinase / 0.651
2p0a ANPSynapsin-3 / 0.650
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.650