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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4p53 NAI 2-epi-5-epi-valiolone synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4p53 NAI2-epi-5-epi-valiolone synthase / 1.260
3zok NAD3-dehydroquinate synthase, chloroplastic 4.2.3.4 0.920
3clh NAD3-dehydroquinate synthase 4.2.3.4 0.868
1nr5 NADPentafunctional AROM polypeptide / 0.856
5hvn NAD3-dehydroquinate synthase / 0.837
3okf NAD3-dehydroquinate synthase 4.2.3.4 0.829
1xag NAD3-dehydroquinate synthase / 0.798
1nvb NADPentafunctional AROM polypeptide / 0.785
3qbd NAD3-dehydroquinate synthase 4.2.3.4 0.774
1sg6 NADPentafunctional AROM polypeptide / 0.773
1xah NAD3-dehydroquinate synthase / 0.766
1xaj NAD3-dehydroquinate synthase / 0.762
1nve NADPentafunctional AROM polypeptide / 0.727
3hl0 NADMaleylacetate reductase / 0.702
1xal NAD3-dehydroquinate synthase / 0.693
5br4 NADLactaldehyde reductase 1.1.1.77 0.687
1rrm APRLactaldehyde reductase 1.1.1.77 0.683
3jzd NADMaleylacetate reductase / 0.662
1jq5 NADGlycerol dehydrogenase 1.1.1.6 0.654
3rf7 NADIron-containing alcohol dehydrogenase / 0.653
1nva ADPPentafunctional AROM polypeptide / 0.652