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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4otp ADP Serine/threonine-protein kinase RIO1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.933
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.778
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.744
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.741
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.738
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.731
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.727
4qny ANPMitogen activated protein kinase, putative / 0.727
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.723
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.720
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.715
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.715
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
5dos ATPAurora kinase A 2.7.11.1 0.714
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.712
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.712
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.710
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.709
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.708
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
1u54 ACPActivated CDC42 kinase 1 / 0.706
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.706
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.706
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.704
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.704
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4xlv ACPInsulin receptor 2.7.10.1 0.700
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.697
5dr2 ATPAurora kinase A 2.7.11.1 0.697
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.696
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.696
5dt3 ATPAurora kinase A 2.7.11.1 0.696
5eg3 ACPFibroblast growth factor receptor 2 / 0.696
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.695
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.693
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.692
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.691
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.690
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.689
1m0w ANPGlutathione synthetase 6.3.2.3 0.688
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.688
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.688
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.686
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.686
5ce3 ADPProtein kinase YopO / 0.686
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.685
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.683
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.682
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.681
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.679
2olc ADPMethylthioribose kinase 2.7.1.100 0.679
2pml ANPUncharacterized protein / 0.679
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.679
5dnr ATPAurora kinase A 2.7.11.1 0.679
2pun ACPMethylthioribose kinase 2.7.1.100 0.677
5dt4 ATPAurora kinase A 2.7.11.1 0.677
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.676
3c4z ADPRhodopsin kinase / 0.676
1ia9 ANPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.675
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4ffr ATPUncharacterized protein / 0.674
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.674
5drd ATPAurora kinase A 2.7.11.1 0.673
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.672
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.671
2vqd AP2Biotin carboxylase 6.3.4.14 0.671
3q5i ANPProtein kinase, putative / 0.671
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.671
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.669
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.669
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4dee ADPAurora kinase A 2.7.11.1 0.667
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.666
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.666
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.666
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.665
3eps ATPIsocitrate dehydrogenase kinase/phosphatase / 0.665
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.664
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.664
1ol6 ATPAurora kinase A 2.7.11.1 0.663
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.663
1ol7 ADPAurora kinase A 2.7.11.1 0.661
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4o1p ANPRibonuclease L / 0.661
1e8x ATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.660
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.660
4ffm ADPUncharacterized protein / 0.660
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
5dn3 ATPAurora kinase A 2.7.11.1 0.660
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.659
5iqb GNPBifunctional AAC/APH 2.3.1 0.659
5iqe GNPBifunctional AAC/APH 2.3.1 0.659
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.658
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
4bn1 ADPAurora kinase A 2.7.11.1 0.658
5l8j ADPAurora kinase A 2.7.11.1 0.658
1wbp ADPSRSF protein kinase 1 2.7.11.1 0.657
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.657
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
1ir3 ANPInsulin receptor 2.7.10.1 0.656
2pwl ACPFibroblast growth factor receptor 2 / 0.656
2yaa ATPDeath-associated protein kinase 2 / 0.656
3orp AGSSerine/threonine protein kinase / 0.656
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.656
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.655
2c6d ANPAurora kinase A 2.7.11.1 0.655
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.654
3llt ANPProtein serine/threonine kinase-1 / 0.654
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.654
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.653
3rv4 ADPBiotin carboxylase 6.3.4.14 0.653
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.653
5iqg GDPBifunctional AAC/APH 2.3.1 0.653
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.652
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.652
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.652
2pui ADPMethylthioribose kinase 2.7.1.100 0.651
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.651
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.651
3ort AGSSerine/threonine protein kinase / 0.651
4o4d ATPKinase / 0.651
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.650
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.650