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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o30 SAH Probable Histone-lysine N-methyltransferase ATXR5 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4o30 SAHProbable Histone-lysine N-methyltransferase ATXR5 2.1.1.43 1.026
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.788
3swc SAHHistone-lysine N-methyltransferase EHMT1 / 0.780
4j83 SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.779
3qwp SAMHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.777
5hq8 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.777
3m53 SAHHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.771
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.771
5jin SAMHistone-lysine N-methyltransferase EHMT2 / 0.771
3cbp SFGHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.770
3tg4 SAMN-lysine methyltransferase SMYD2 / 0.766
4o6f SAHN-lysine methyltransferase SMYD2 / 0.757
5ex0 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.756
4qen SAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 2.1.1.43 0.754
1n6c SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.752
2o8j SAHHistone-lysine N-methyltransferase EHMT2 / 0.746
3oxf SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.744
4ype SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.739
3ru0 SFGHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.736
3pdn SFGHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.735
4h12 SAHHistone-lysine N-methyltransferase SETD2 2.1.1.43 0.729
2rfi SAHHistone-lysine N-methyltransferase EHMT1 / 0.726
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.726
2bqz SAHN-lysine methyltransferase KMT5A / 0.722
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.722
5czy SAMEukaryotic huntingtin interacting protein B / 0.721
2h21 SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.719
1mlv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.718
1p0y SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.714
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.712
3hna SAHHistone-lysine N-methyltransferase EHMT1 / 0.705
3fpd SAHHistone-lysine N-methyltransferase EHMT1 / 0.702
4z4p SAHHistone-lysine N-methyltransferase 2D 2.1.1.43 0.690
3kmt SAHHistone H3K27 methylase / 0.683
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.682
4ynm SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.681
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.680
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.678
2h23 SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.675
2zdg ADPD-alanine--D-alanine ligase / 0.669
3keu ATPPyridoxal kinase 2.7.1.35 0.668
3n71 SFGHistone-lysine N-methyltransferase Smyd1 / 0.668
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.665
1olt SAMOxygen-independent coproporphyrinogen III oxidase / 0.659
4mv3 ACPBiotin carboxylase 6.3.4.14 0.657
1ozv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.655
3rib SAHN-lysine methyltransferase SMYD2 / 0.653
4ypu SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.653
2eka SAHDiphthine synthase / 0.650
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650