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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o2z 046 Mitogen-activated protein kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4o2z 046Mitogen-activated protein kinase / 1.257
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.736
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.716
3gcs BAXMitogen-activated protein kinase 14 / 0.700
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.698
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.697
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.694
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.693
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.690
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.685
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.666
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.659
3p7c P7CMitogen-activated protein kinase 14 / 0.653