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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nwz FAD FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 1.215
4hb9 FADUncharacterized protein / 0.819
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.775
4x4j FADPutative oxygenase / 0.746
4wct FADFructosyl amine:oxygen oxidoreductase / 0.744
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.742
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.742
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.738
3k4c FADPyranose 2-oxidase / 0.734
3pl8 FADPyranose 2-oxidase / 0.733
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.731
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.730
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.730
4gut FADLysine-specific histone demethylase 1B 1 0.728
3ad9 FADSubunit beta of sarcosine oxidase / 0.726
4bk3 FADProbable salicylate monooxygenase / 0.726
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.723
4opc FDAConserved Archaeal protein / 0.723
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.722
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.722
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.722
3lsh FADPyranose 2-oxidase / 0.720
4mok FADPyranose 2-oxidase / 0.720
1knr FADL-aspartate oxidase 1.4.3.16 0.719
2ign FADPyranose 2-oxidase / 0.719
4k2x FADPolyketide oxygenase/hydroxylase / 0.718
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.715
3cn8 FADPolyamine oxidase FMS1 / 0.715
3qvr FADGlucose oxidase 1.1.3.4 0.712
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.711
2y48 FADLysine-specific histone demethylase 1A 1 0.710
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.710
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.709
2q7v FADThioredoxin reductase / 0.708
3qvp FADGlucose oxidase 1.1.3.4 0.707
4fwf FADLysine-specific histone demethylase 1B 1 0.706
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.705
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.705
4j33 FADKynurenine 3-monooxygenase / 0.705
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.704
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.704
2xdo FADTetX family tetracycline inactivation enzyme / 0.704
2b9x FADPutative aminooxidase / 0.703
4at0 FADPossible succinate dehydrogenase / 0.703
4opg FDAConserved Archaeal protein / 0.703
2q0k FADThioredoxin reductase 1.8.1.9 0.702
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.702
4ccq FADThioredoxin reductase / 0.702
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.702
1tdf FADThioredoxin reductase 1.8.1.9 0.701
4opl FDAConserved Archaeal protein / 0.701
4opu FDAConserved Archaeal protein / 0.701
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.700
4guu FA9Lysine-specific histone demethylase 1B 1 0.699
1qo8 FADFumarate reductase flavoprotein subunit / 0.698
4fwe FADLysine-specific histone demethylase 1B 1 0.698
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.698
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
4gdp FADPolyamine oxidase FMS1 / 0.697
4opi FDAConserved Archaeal protein / 0.697
4opt FDAConserved Archaeal protein / 0.697
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.697
3bi2 FADPolyamine oxidase FMS1 / 0.696
1cf3 FADGlucose oxidase 1.1.3.4 0.695
3bg7 FADPyranose 2-oxidase / 0.695
3cnd FADPolyamine oxidase FMS1 / 0.695
2r9z FADGlutathione amide reductase / 0.694
2yg4 FADPutrescine oxidase / 0.694
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.693
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.693
3lsi FADPyranose 2-oxidase / 0.693
4gcm FADThioredoxin reductase 1.8.1.9 0.693
2tpr FADTrypanothione reductase 1.8.1.12 0.692
3k4n FADPyranose 2-oxidase / 0.692
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.692
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.691
3ish FADThioredoxin reductase 1.8.1.9 0.691
3lsm SFDPyranose 2-oxidase / 0.691
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.690
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
1zk7 FADMercuric reductase 1.16.1.1 0.689
1tde FADThioredoxin reductase 1.8.1.9 0.688
1feb FADTrypanothione reductase 1.8.1.12 0.687
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
2yqu FADDihydrolipoyl dehydrogenase / 0.687
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.687
4bjz FADProbable salicylate monooxygenase / 0.686
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.686
1trb FADThioredoxin reductase 1.8.1.9 0.685
2igo FADPyranose 2-oxidase / 0.685
3cgc FADCoenzyme A disulfide reductase / 0.685
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.685
4c5o FADPutative monooxygenase / 0.685
2v6o FADThioredoxin glutathione reductase / 0.684
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.684
5j60 FADThioredoxin reductase / 0.684
2zbw FADFerredoxin--NADP reductase / 0.683
3ict FADCoenzyme A disulfide reductase / 0.682
3t2k FADSulfide-quinone reductase / 0.682
3k30 ADPHistamine dehydrogenase / 0.681
4mih FADPyranose 2-oxidase 1.1.3.10 0.681
1fec FADTrypanothione reductase 1.8.1.12 0.680
1joa FADNADH peroxidase 1.11.1.1 0.680
2cdu FADNADH oxidase / 0.680
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.679
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.679
2h94 FADLysine-specific histone demethylase 1A 1 0.679
2x3n FADProbable FAD-dependent monooxygenase / 0.679
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.679
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.679
1gpe FADGlucose oxidase 1.1.3.4 0.677
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.677
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.677
2yvj FADFerredoxin reductase / 0.677
3cgb FADCoenzyme A disulfide reductase / 0.677
3dme FADPutative conserved exported protein / 0.677
2bab FADPutative aminooxidase / 0.676
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
3t37 FADPyridoxine 4-oxidase / 0.676
3v76 FDAUncharacterized protein / 0.676
2cdu ADPNADH oxidase / 0.675
2bac FADPutative aminooxidase / 0.674
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.673
3gyj FADCholesterol oxidase 1.1.3.6 0.673
3rp8 FADFAD-dependent urate hydroxylase / 0.673
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.672
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.672
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.671
2q0l FADThioredoxin reductase 1.8.1.9 0.671
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
3jsk AHZThiamine thiazole synthase / 0.671
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.671
5hsa FASAlcohol oxidase 1 1.1.3.13 0.671
4rek FADCholesterol oxidase 1.1.3.6 0.670
2eq6 FADDihydrolipoyl dehydrogenase / 0.669
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.669
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.668
2eq7 NADDihydrolipoyl dehydrogenase / 0.668
2qa2 FADPolyketide oxygenase CabE / 0.668
3f8d FADNADH oxidase/thioredoxin reductase / 0.668
3icr FADCoenzyme A disulfide reductase / 0.668
3vqr FADPutative oxidoreductase / 0.668
4c3y FAD3-ketosteroid dehydrogenase / 0.668
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.668
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.667
1q1w FADPutidaredoxin reductase 1.18.1.5 0.667
1ng4 FADGlycine oxidase 1.4.3.19 0.666
4jnq FDAThioredoxin reductase / 0.666
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.666
1b4v FADCholesterol oxidase 1.1.3.6 0.665
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.665
2eq7 FADDihydrolipoyl dehydrogenase / 0.665
2vvl FADMonoamine oxidase N 1.4.3.4 0.665
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.665
4cnj FADL-amino acid oxidase / 0.665
1knp FADL-aspartate oxidase 1.4.3.16 0.664
3lov FADProtoporphyrinogen oxidase / 0.664
1gal FADGlucose oxidase 1.1.3.4 0.663
1ng3 FADGlycine oxidase 1.4.3.19 0.663
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.663
4ccr FADThioredoxin reductase / 0.663
4up3 FADThioredoxin reductase / 0.663
1f8w FADNADH peroxidase 1.11.1.1 0.662
2b9y FADPutative aminooxidase / 0.662
2ba9 FADPutative aminooxidase / 0.662
2eq8 FADDihydrolipoyl dehydrogenase / 0.662
2xvf FADPutative flavin-containing monooxygenase / 0.662
4em3 FADCoenzyme A disulfide reductase / 0.662
4jq9 FADDihydrolipoyl dehydrogenase / 0.662
4cnk FADL-amino acid oxidase / 0.661
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.660
1q1r FADPutidaredoxin reductase 1.18.1.5 0.660
3ae4 FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.660
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.660
4x9n FADUncharacterized protein MG039 homolog / 0.660
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
2rgh FADAlpha-Glycerophosphate Oxidase / 0.659
3fg2 FADPutative rubredoxin reductase / 0.659
3ka7 FADPutative oxidoreductase / 0.659
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.658
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.658
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.658
4gur FADLysine-specific histone demethylase 1B 1 0.658
4hsu FADLysine-specific histone demethylase 1B 1 0.658
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.658
1h83 FADPolyamine oxidase 1.5.3.14 0.657
3axb FADPutative oxidoreductase / 0.657
3cox FADCholesterol oxidase 1.1.3.6 0.657
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
3fbs FADOxidoreductase / 0.657
4b1b FADThioredoxin reductase 1.8.1.9 0.657
4yry FADGlutamate synthase, beta subunit / 0.657
4a5l FADThioredoxin reductase / 0.656
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
4z24 FADPutative GMC-type oxidoreductase R135 1 0.656
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.656
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
2a87 FADThioredoxin reductase 1.8.1.9 0.655
2b9w FADPutative aminooxidase / 0.655
4yac NAIC alpha-dehydrogenase / 0.655
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.654
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.654
3urh FADDihydrolipoyl dehydrogenase / 0.654
3zdn FADMonoamine oxidase N 1.4.3.4 0.654
4dna FADProbable glutathione reductase / 0.654
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.654
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
1nhs FADNADH peroxidase 1.11.1.1 0.653
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.653
2qa1 FADPgaE / 0.653
4aox FADSteroid monooxygenase / 0.653
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
1ger FADGlutathione reductase 1.8.1.7 0.652
1nhr FADNADH peroxidase 1.11.1.1 0.652
3cge FADCoenzyme A disulfide reductase / 0.652
3fpz AHZThiamine thiazole synthase / 0.652
3kpk FADSulfide-quinone reductase / 0.652
3nlc FADUncharacterized protein / 0.652
3cuk FADD-amino-acid oxidase 1.4.3.3 0.651
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.651
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.651
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.650
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.650
2npx FADNADH peroxidase 1.11.1.1 0.650
3cgd FADCoenzyme A disulfide reductase / 0.650
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.650
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.650
3qj4 FADRenalase / 0.650