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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ntc FAD Thioredoxin reductase gliT

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4ntc FADThioredoxin reductase gliT / 1.405
3fbs FADOxidoreductase / 0.934
4jn9 FADDepH / 0.901
4ntd FADThioredoxin reductase / 0.891
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.866
1tdf FADThioredoxin reductase 1.8.1.9 0.865
4nte FADDepH / 0.864
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.855
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.839
4opd FDAConserved Archaeal protein / 0.838
1tde FADThioredoxin reductase 1.8.1.9 0.834
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.834
2v6o FADThioredoxin glutathione reductase / 0.832
2zbw FADFerredoxin--NADP reductase / 0.832
2eq6 FADDihydrolipoyl dehydrogenase / 0.828
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.827
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.820
3atq FDAConserved Archaeal protein / 0.818
4fwf FADLysine-specific histone demethylase 1B 1 0.811
2r9z FADGlutathione amide reductase / 0.808
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.806
4opu FDAConserved Archaeal protein / 0.806
4opi FDAConserved Archaeal protein / 0.804
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.802
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.800
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.799
4guu FA9Lysine-specific histone demethylase 1B 1 0.798
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.796
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.795
4fk1 FADPutative thioredoxin reductase / 0.795
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.794
2eq8 FADDihydrolipoyl dehydrogenase / 0.794
4opg FDAConserved Archaeal protein / 0.791
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.786
2eq9 FADDihydrolipoyl dehydrogenase / 0.785
3icr FADCoenzyme A disulfide reductase / 0.783
3urh FADDihydrolipoyl dehydrogenase / 0.783
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.782
2w0h FADTrypanothione reductase / 0.780
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.780
4j57 FADThioredoxin reductase 2 1.8.1.9 0.780
4opt FDAConserved Archaeal protein / 0.780
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.778
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.773
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.773
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.772
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.771
4nev FADTrypanothione reductase / 0.771
1geu FADGlutathione reductase 1.8.1.7 0.770
4opc FDAConserved Archaeal protein / 0.770
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.769
2hqm FADGlutathione reductase 1.8.1.7 0.767
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.766
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.766
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.765
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.765
3lad FADDihydrolipoyl dehydrogenase / 0.765
1get FADGlutathione reductase 1.8.1.7 0.763
1bzl FADTrypanothione reductase 1.8.1.12 0.762
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.762
4i58 FADCyclohexylamine Oxidase / 0.762
2yqu FADDihydrolipoyl dehydrogenase / 0.761
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.758
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.758
1zk7 FADMercuric reductase 1.16.1.1 0.757
3atr FDAConserved Archaeal protein / 0.757
3ict FADCoenzyme A disulfide reductase / 0.756
2yg4 FADPutrescine oxidase / 0.755
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.754
2tpr FADTrypanothione reductase 1.8.1.12 0.752
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.752
4la1 FADThioredoxin glutathione reductase / 0.752
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.751
3cgc FADCoenzyme A disulfide reductase / 0.750
3cgb FADCoenzyme A disulfide reductase / 0.749
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.748
2q7v FADThioredoxin reductase / 0.748
2wow FADTrypanothione reductase / 0.748
4opl FDAConserved Archaeal protein / 0.748
2qa1 FADPgaE / 0.747
2x8g FADThioredoxin glutathione reductase / 0.747
4j2w FADKynurenine 3-monooxygenase / 0.747
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.746
3ept FDAPutative FAD-monooxygenase / 0.746
1rsg FADPolyamine oxidase FMS1 / 0.745
2rab FADGlutathione amide reductase / 0.745
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.744
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.742
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.741
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.740
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.740
5buk FADFADH2-dependent halogenase / 0.740
2x8h FADThioredoxin glutathione reductase / 0.739
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.739
4gus FADLysine-specific histone demethylase 1B 1 0.739
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.738
4j36 FADKynurenine 3-monooxygenase / 0.737
4j31 FADKynurenine 3-monooxygenase / 0.736
4j34 FADKynurenine 3-monooxygenase / 0.736
2npx FADNADH peroxidase 1.11.1.1 0.732
1cl0 FADThioredoxin reductase 1.8.1.9 0.731
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.731
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.730
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.729
3cgd FADCoenzyme A disulfide reductase / 0.728
1ger FADGlutathione reductase 1.8.1.7 0.727
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.727
4k5r FADOxygenase / 0.727
2jk6 FADTrypanothione reductase / 0.726
3bi2 FADPolyamine oxidase FMS1 / 0.726
3f8p NADNADH oxidase/thioredoxin reductase / 0.726
3ish FADThioredoxin reductase 1.8.1.9 0.726
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.726
4hb9 FADUncharacterized protein / 0.726
1xpq FADPolyamine oxidase FMS1 / 0.725
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.725
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.725
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.725
4j33 FADKynurenine 3-monooxygenase / 0.725
2q0k FADThioredoxin reductase 1.8.1.9 0.723
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.722
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.722
2ywl FADThioredoxin reductase related protein / 0.722
3ics FADCoenzyme A disulfide reductase / 0.722
2eq7 FADDihydrolipoyl dehydrogenase / 0.721
1trb FADThioredoxin reductase 1.8.1.9 0.720
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.720
1ges FADGlutathione reductase 1.8.1.7 0.719
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.719
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.719
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.718
2cul FADGidA-related protein / 0.718
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.718
4a65 FADThioredoxin reductase / 0.718
4gcm FADThioredoxin reductase 1.8.1.9 0.718
1nhr FADNADH peroxidase 1.11.1.1 0.717
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.716
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.716
3d8x FADThioredoxin reductase 1 1.8.1.9 0.716
3itj FADThioredoxin reductase 1 1.8.1.9 0.716
4bk2 FADProbable salicylate monooxygenase / 0.716
4k2x FADPolyketide oxygenase/hydroxylase / 0.716
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.716
2cdu FADNADH oxidase / 0.715
3cnd FADPolyamine oxidase FMS1 / 0.713
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.713
4cnk FADL-amino acid oxidase / 0.713
1zx9 FADMercuric reductase 1.16.1.1 0.712
1npx FADNADH peroxidase 1.11.1.1 0.711
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.711
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.710
1nhp FADNADH peroxidase 1.11.1.1 0.709
1nhq FADNADH peroxidase 1.11.1.1 0.709
4a6n FADTetX family tetracycline inactivation enzyme / 0.709
4bjz FADProbable salicylate monooxygenase / 0.708
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
2gr3 FADFerredoxin reductase / 0.707
3hdy FDAUDP-galactopyranose mutase / 0.707
3vqr FADPutative oxidoreductase / 0.707
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.706
1k0j FADp-hydroxybenzoate hydroxylase / 0.706
1tyt FADTrypanothione reductase 1.8.1.12 0.706
1d7y FADFerredoxin reductase / 0.705
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.705
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.705
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.704
3cge FADCoenzyme A disulfide reductase / 0.704
4bk3 FADProbable salicylate monooxygenase / 0.704
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.704
4ynt FDAGlucose oxidase, putative / 0.704
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.703
4a5l FADThioredoxin reductase / 0.703
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.703
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.702
2cvj FADThioredoxin reductase related protein / 0.701
3f8d FADNADH oxidase/thioredoxin reductase / 0.699
3zdn FADMonoamine oxidase N 1.4.3.4 0.699
1d7l RFLp-hydroxybenzoate hydroxylase / 0.698
4emw FADCoenzyme A disulfide reductase / 0.698
4jnq FDAThioredoxin reductase / 0.698
4wct FADFructosyl amine:oxygen oxidoreductase / 0.698
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.697
4ccq FADThioredoxin reductase / 0.697
2xdo FADTetX family tetracycline inactivation enzyme / 0.696
4a99 FADTetX family tetracycline inactivation enzyme / 0.696
2wba FADTrypanothione reductase 1.8.1.12 0.694
3f8r NAPNADH oxidase/thioredoxin reductase / 0.694
1f3p FADFerredoxin reductase / 0.693
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.693
2b9w FADPutative aminooxidase / 0.693
1gxf FADTrypanothione reductase 1.8.1.12 0.692
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.692
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.692
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.691
1f8w FADNADH peroxidase 1.11.1.1 0.690
2ign FADPyranose 2-oxidase / 0.690
3a3b RBFLumazine protein / 0.690
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.690
5j60 FADThioredoxin reductase / 0.690
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4j56 FADThioredoxin reductase 2 1.8.1.9 0.689
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.689
3lsi FADPyranose 2-oxidase / 0.688
1ryi FADGlycine oxidase 1.4.3.19 0.687
3cty FADProbable thioredoxin reductase / 0.687
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.687
2du8 FADD-amino-acid oxidase 1.4.3.3 0.686
2iw5 FADLysine-specific histone demethylase 1A 1 0.686
4ccr FADThioredoxin reductase / 0.686
4up3 FADThioredoxin reductase / 0.686
4yjd FADD-amino-acid oxidase 1.4.3.3 0.686
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.686
1knp FADL-aspartate oxidase 1.4.3.16 0.685
3r9u FADThioredoxin reductase / 0.685
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.685
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.685
1c0l FADD-amino-acid oxidase 1.4.3.3 0.684
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.684
2whd FADThioredoxin reductase / 0.684
2x3n FADProbable FAD-dependent monooxygenase / 0.684
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.684
3syi FADSulfide-quinone reductase / 0.684
3v76 FDAUncharacterized protein / 0.684
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.684
3axb FADPutative oxidoreductase / 0.683
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.683
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.683
2qa2 FADPolyketide oxygenase CabE / 0.682
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.682
1cbo FADCholesterol oxidase 1.1.3.6 0.681
2xyo FADTetX family tetracycline inactivation enzyme / 0.681
1pdh FASp-hydroxybenzoate hydroxylase / 0.680
3mj4 FADUDP-galactopyranose mutase / 0.680
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.679
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.678
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.678
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.678
1cc2 FADCholesterol oxidase 1.1.3.6 0.677
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.677
2gqw FADFerredoxin reductase / 0.677
3cn8 FADPolyamine oxidase FMS1 / 0.677
3lsm SFDPyranose 2-oxidase / 0.677
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.677
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.676
1q1w FADPutidaredoxin reductase 1.18.1.5 0.676
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.676
4dna FADProbable glutathione reductase / 0.676
2gr0 FADFerredoxin reductase / 0.675
4mih FADPyranose 2-oxidase 1.1.3.10 0.675
2pia FMNPhthalate dioxygenase reductase / 0.674
3lsh FADPyranose 2-oxidase / 0.674
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.673
2vvl FADMonoamine oxidase N 1.4.3.4 0.673
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.673
4mok FADPyranose 2-oxidase / 0.673
2q0l FADThioredoxin reductase 1.8.1.9 0.672
3ad9 NADSubunit alpha of sarocosine oxidase / 0.672
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.672
4eqw FADCoenzyme A disulfide reductase / 0.671
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.670
4cbq FADThioredoxin reductase / 0.669
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.667
3cuk FADD-amino-acid oxidase 1.4.3.3 0.667
4eqx FADCoenzyme A disulfide reductase / 0.667
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.667
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.667
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.666
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.666
2yg6 FADPutrescine oxidase / 0.666
4eqs FADCoenzyme A disulfide reductase / 0.666
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.666
1ng3 FADGlycine oxidase 1.4.3.19 0.665
2bac FADPutative aminooxidase / 0.665
3nix FADFlavoprotein/dehydrogenase / 0.665
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.664
4ysh FADGlycine oxidase / 0.663
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.662
4b1b FADThioredoxin reductase 1.8.1.9 0.662
1h81 FADPolyamine oxidase 1.5.3.14 0.661
4gdp FADPolyamine oxidase FMS1 / 0.661
3rp8 FADFAD-dependent urate hydroxylase / 0.660
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.660
3nlc FADUncharacterized protein / 0.659
1fec FADTrypanothione reductase 1.8.1.12 0.658
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.658
2igo FADPyranose 2-oxidase / 0.658
2y48 FADLysine-specific histone demethylase 1A 1 0.658
4b69 FADL-ornithine N(5)-monooxygenase / 0.658
4em4 FADCoenzyme A disulfide reductase / 0.658
1feb FADTrypanothione reductase 1.8.1.12 0.657
2gqf FADUncharacterized protein HI_0933 / 0.657
3jsk AHZThiamine thiazole synthase / 0.657
4em3 FADCoenzyme A disulfide reductase / 0.657
4gut FADLysine-specific histone demethylase 1B 1 0.657
1kif FADD-amino-acid oxidase 1.4.3.3 0.656
2b9y FADPutative aminooxidase / 0.656
3fmw FADOxygenase / 0.656
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.656
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.655
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.655
3kpk FADSulfide-quinone reductase / 0.655
4fwj FADLysine-specific histone demethylase 1B 1 0.655
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.655
4mo2 FADUDP-galactopyranose mutase / 0.654
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.653
2ba9 FADPutative aminooxidase / 0.653
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.653
5dbj FADFADH2-dependent halogenase PltA / 0.653
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.652
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.652
2bab FADPutative aminooxidase / 0.651
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.651
3pl8 FADPyranose 2-oxidase / 0.651
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.651
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.651
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.650
1k0l FADp-hydroxybenzoate hydroxylase / 0.650
1z6l FADPolyamine oxidase FMS1 / 0.650
2gv8 FADThiol-specific monooxygenase 1.14.13 0.650
2gvc FADThiol-specific monooxygenase 1.14.13 0.650
3gyj FADCholesterol oxidase 1.1.3.6 0.650
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.650
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.650
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.650
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.650
4mo2 FDAUDP-galactopyranose mutase / 0.650