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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nm0 ADP Glycogen synthase kinase-3 beta 2.7.11.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.915
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.740
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.730
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.717
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.717
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.714
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.706
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.706
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.700
2olc ADPMethylthioribose kinase 2.7.1.100 0.698
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.695
1cm8 ANPMitogen-activated protein kinase 12 / 0.691
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.688
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.687
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.685
3b2t M33Fibroblast growth factor receptor 2 / 0.683
5dos ATPAurora kinase A 2.7.11.1 0.683
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
3wo1 ADPAlanine--anticapsin ligase / 0.682
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.682
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.681
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.681
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.680
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.679
4ix5 ANPUncharacterized protein / 0.679
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
5dt4 ATPAurora kinase A 2.7.11.1 0.678
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.677
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.677
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.675
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
4q5h ANPProtein kinase OspG 2.7 0.673
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.672
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.670
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.669
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.667
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.667
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.666
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.664
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.661
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.660
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.660
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.659
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.657
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.656
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.656
3qc9 ADPRhodopsin kinase / 0.656
4n57 ADPAPH(2'')-Id / 0.656
5dr2 ATPAurora kinase A 2.7.11.1 0.656
4ysj ADPCalmodulin-like domain protein kinase / 0.655
3bu5 ATPInsulin receptor 2.7.10.1 0.654
4dt8 ADNAPH(2'')-Id / 0.654
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.652
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.652
3t8o ATPRhodopsin kinase / 0.652
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.652
4fu0 ADPD-alanine--D-alanine ligase / 0.652
5dt3 ATPAurora kinase A 2.7.11.1 0.652
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.651
4utd ACPAurora kinase A 2.7.11.1 0.651
4xlv ACPInsulin receptor 2.7.10.1 0.651
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.650
2yaa ATPDeath-associated protein kinase 2 / 0.650
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.650
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650