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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nky 3QZ Steroid 17-alpha-hydroxylase/17,20 lyase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 1.069
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.726
2aa6 STRMineralocorticoid receptor / 0.714
3s79 ASDAromatase 1.14.14.14 0.714
2ab2 SNLMineralocorticoid receptor / 0.711
3vhu SNLMineralocorticoid receptor / 0.702
1kdm DHTSex hormone-binding globulin / 0.697
3eqm ASDAromatase 1.14.14.14 0.694
2mm3 CHOGastrotropin / 0.693
4j6d TESCytochrome P450 monooxygenase / 0.682
1fds ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.681
3gki CLRNiemann-Pick C1 protein / 0.680
3mnp DEXGlucocorticoid receptor / 0.678
4r21 STRCytochrome P450 family 17 polypeptide 2 / 0.678
1sqn NDRProgesterone receptor / 0.677
4bqu CLRJapanin / 0.676
1f5f DHTSex hormone-binding globulin / 0.675
5dxg ESTEstrogen receptor / 0.674
2y00 Y01Beta-1 adrenergic receptor / 0.672
2ft9 CHDFatty acid-binding protein 2, liver / 0.670
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.670
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.670
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.669
1lhu ESTSex hormone-binding globulin / 0.669
4p6x HCYGlucocorticoid receptor / 0.669
1fdt ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.667
3l0l HC3Nuclear receptor ROR-gamma / 0.663
4l1x STRAldo-keto reductase family 1 member C2 / 0.663
2jn3 JN3Fatty acid-binding protein, liver / 0.662
4r20 AERCytochrome P450 family 17 polypeptide 2 / 0.662
2b04 CHOPhospholipase A2, major isoenzyme 3.1.1.4 0.661
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1lhv NOGSex hormone-binding globulin / 0.659
2b1z 17MEstrogen receptor / 0.659
2j7x ESTEstrogen receptor beta / 0.659
2cbo TH2Neocarzinostatin / 0.658
2yja ESTEstrogen receptor / 0.658
2b01 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.657
1y9r 1CAMineralocorticoid receptor / 0.655
3bej MUFBile acid receptor / 0.655
3uud ESTEstrogen receptor / 0.652
1gwr ESTEstrogen receptor / 0.651