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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nke RIS Farnesyl pyrophosphate synthase 2.5.1.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 1.120
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 1.046
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.959
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.916
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.908
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.905
4h5c YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.889
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.887
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.885
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.882
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.880
3ldw ZOLFarnesyl pyrophosphate synthase, putative / 0.879
2f94 BFQFarnesyl pyrophosphate synthase 2.5.1.10 0.871
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.869
3icz PB6Farnesyl pyrophosphate synthase / 0.864
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.860
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.858
3dyh 721Farnesyl pyrophosphate synthase / 0.847
4dxj 0M9Farnesyl pyrophosphate synthase / 0.846
4dwb 0M7Farnesyl pyrophosphate synthase / 0.839
2e95 B75Geranylgeranyl pyrophosphate synthase / 0.821
3egt 722Farnesyl pyrophosphate synthase / 0.820
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.820
2o1o RISPutative farnesyl pyrophosphate synthase / 0.814
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.804
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.788
5erm 210Fusicoccadiene synthase 4.2.3.43 0.757
2z4w 749Geranylgeranyl pyrophosphate synthase / 0.742
2i19 1BYFarnesyl pyrophosphate synthase / 0.741
4l2x YL2Farnesyl pyrophosphate synthase 2.5.1.10 0.741
2e91 ZOLGeranylgeranyl pyrophosphate synthase / 0.721
3dt4 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.713
5ero 210Fusicoccadiene synthase 2.5.1.29 0.711
1khb GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.702
3ryw K9HFarnesyl pyrophosphate synthase, putative / 0.702
2py7 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.695
2q36 ATPActin, alpha skeletal muscle / 0.694
2zev B71Geranylgeranyl pyrophosphate synthase / 0.688
1t44 ATPActin, alpha skeletal muscle / 0.687
2olr ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.680
2opm NI9Farnesyl pyrophosphate synthase 2.5.1.10 0.680
2e93 B29Geranylgeranyl pyrophosphate synthase / 0.679
2z4z SC0Geranylgeranyl pyrophosphate synthase / 0.679
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.673
1mdu ATPActin, alpha skeletal muscle / 0.671
2z4y 252Geranylgeranyl pyrophosphate synthase / 0.670
1mdl SMNMandelate racemase / 0.669
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.669
2bc9 GNPGuanylate-binding protein 1 / 0.663
2jj2 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.663
3orl AGSSerine/threonine protein kinase / 0.662
4jvj 1MVFarnesyl pyrophosphate synthase 2.5.1.10 0.660
1lot ATPActin, alpha skeletal muscle / 0.657
2gqr ADPPhosphoribosylaminoimidazole-succinocarboxamide synthase 6.3.2.6 0.657
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.656
1mb9 ATPCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.655
4fvq ATPTyrosine-protein kinase JAK2 / 0.655
4qfz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.655
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.653
4n9q FMNFMN-dependent NADH-azoreductase 1 / 0.652
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.651
4dqw ATPInosine-5'-monophosphate dehydrogenase / 0.651
4mrt COA4'-phosphopantetheinyl transferase sfp 2.7.8 0.651
1esn ANPPantothenate kinase 2.7.1.33 0.650