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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nka 2K7 Fibroblast growth factor receptor 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nka 2K7Fibroblast growth factor receptor 1 / 1.107
4f64 0S8Fibroblast growth factor receptor 1 / 0.799
4f63 0S7Fibroblast growth factor receptor 1 / 0.727
3w16 P9JAurora kinase A 2.7.11.1 0.722
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.718
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.696
4nks 2M2Fibroblast growth factor receptor 1 / 0.692
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.690
4f65 0S9Fibroblast growth factor receptor 1 / 0.681
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.668
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.667
1uu8 BI13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.662
3ggf GVDSerine/threonine-protein kinase 26 / 0.659
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.659
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.656
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.655
4c62 XWWTyrosine-protein kinase JAK2 / 0.655
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.655
4agc AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.654
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.654
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.651