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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nhm UN9 Prolyl 3,4-dihydroxylase TPA1 1.14.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.899
4bqw QNMEgl nine homolog 1 / 0.759
4bqy FNTEgl nine homolog 1 / 0.740
2g1m 4HGEgl nine homolog 1 / 0.702
3tqb FOLDihydrofolate reductase / 0.692
1hfq MOTDihydrofolate reductase 1.5.1.3 0.685
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.679
4x5h FOLDihydrofolate reductase 1.5.1.3 0.674
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.672
2x1e X1EAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form 2.3.1.164 0.670
4kou C04Uncharacterized protein / 0.669
1re7 FOLDihydrofolate reductase 1.5.1.3 0.664
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.662
4dfr MTXDihydrofolate reductase 1.5.1.3 0.662
4kos 4KOUncharacterized protein / 0.661
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.660
3drc MTXDihydrofolate reductase 1.5.1.3 0.660
1dls MTXDihydrofolate reductase 1.5.1.3 0.659
1dyh DZFDihydrofolate reductase 1.5.1.3 0.659
3fbc TYDNucleoside diphosphate kinase 2.7.4.6 0.659
3fvu IACKynurenine--oxoglutarate transaminase 1 2.6.1.7 0.659
4nhy PD2Prolyl 3-hydroxylase OGFOD1 1.14.11 0.657
1nmq 160Caspase-3 3.4.22.56 0.653
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.653
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.653
4yau 2AMNADPH--cytochrome P450 reductase / 0.653
4yal 2AMNADPH--cytochrome P450 reductase / 0.651
3au2 DGTDNA polymerase beta family (X family) / 0.650