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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4neu Q1A Receptor-interacting serine/threonine-protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 1.255
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.754
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.746
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.733
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.726
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.724
3pg3 DG7Mitogen-activated protein kinase 14 / 0.720
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.720
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.714
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.709
3gcq 1BUMitogen-activated protein kinase 14 / 0.708
3lfe Z84Mitogen-activated protein kinase 14 / 0.702
3lfb Z87Mitogen-activated protein kinase 14 / 0.699
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.689
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.687
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
3lff Z83Mitogen-activated protein kinase 14 / 0.680
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.680
3gcs BAXMitogen-activated protein kinase 14 / 0.679
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.678
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.676
3o8u BMUMitogen-activated protein kinase 14 / 0.675
3o8t BMUMitogen-activated protein kinase 14 / 0.673
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.669
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.668
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.667
3hv3 R49Mitogen-activated protein kinase 14 / 0.667
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.666
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.664
3nnw EDDMitogen-activated protein kinase 14 / 0.663
3uvr 06FMitogen-activated protein kinase 14 / 0.663
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.663
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.661
3ugc 046Tyrosine-protein kinase JAK2 / 0.659
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
3o8p BMUMitogen-activated protein kinase 14 / 0.656
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.654