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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mxx DB8 Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mxx DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.065
3ue4 DB8Tyrosine-protein kinase ABL1 2.7.10.2 0.782
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.769
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.762
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.762
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.674
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.669
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.667
1m17 AQ4Epidermal growth factor receptor 2.7.10.1 0.664
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.658
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.654
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.650