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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mpp TZD Benzoylformate decarboxylase 4.1.1.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 1.143
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 1.100
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 1.085
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 1.073
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 1.071
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 1.064
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 1.064
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 1.062
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 1.062
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 1.060
4qel TZDBenzoylformate decarboxylase 4.1.1.7 1.060
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 1.059
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 1.056
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 1.052
4juf TPPBenzoylformate decarboxylase 4.1.1.7 1.028
4jub TPPBenzoylformate decarboxylase 4.1.1.7 1.026
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 1.007
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.999
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.998
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.994
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.985
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.979
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.975
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.974
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.967
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.881
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.870
4cok TPPPyruvate decarboxylase / 0.870
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.862
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.831
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.820
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.817
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.816
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.812
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.805
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.805
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.803
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.801
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.798
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.796
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.793
2pan TDPGlyoxylate carboligase 4.1.1.47 0.790
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.789
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.788
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.787
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.784
1pox TPPPyruvate oxidase 1.2.3.3 0.782
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.781
1y9d TPPPyruvate oxidase 1.2.3.3 0.780
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.780
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.779
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.773
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.761
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.761
5c4i TPPOxalate oxidoreductase subunit alpha / 0.759
5c4i TPPOxalate oxidoreductase subunit beta / 0.759
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.755
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.750
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.747
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.747
1pow TPPPyruvate oxidase 1.2.3.3 0.742
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.741
1kek HTLPyruvate synthase / 0.740
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.740
3ahi HTLProbable phosphoketolase / 0.738
2ez9 TDKPyruvate oxidase 1.2.3.3 0.733
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.731
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.731
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.724
3d7k D7KBenzaldehyde lyase / 0.720
2ezt TDMPyruvate oxidase 1.2.3.3 0.719
2r8o T5XTransketolase 1 / 0.719
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.717
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.717
2uza HTLPyruvate synthase / 0.714
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.713
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.712
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.712
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.712
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.712
3m6l TPPTransketolase / 0.712
1tkc M6TTransketolase 1 2.2.1.1 0.710
3m34 TPPTransketolase / 0.708
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.707
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.707
2ag0 TPPBenzaldehyde lyase / 0.705
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.704
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.703
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.698
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.698
3iae D7KBenzaldehyde lyase / 0.697
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.695
1gpu THDTransketolase 1 2.2.1.1 0.694
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.694
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.693
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.693
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.693
4c7x TPPTransketolase / 0.690
1ngs TPPTransketolase 1 2.2.1.1 0.688
1ay0 TPPTransketolase 1 2.2.1.1 0.687
2pda TPPPyruvate synthase / 0.687
3ahj TPPProbable phosphoketolase / 0.687
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.685
3m7i TPPTransketolase / 0.684
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.684
5ahk TPPAcetolactate synthase II, large subunit / 0.684
1trk TPPTransketolase 1 2.2.1.1 0.681
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.679
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.679
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.678
3ahe THDProbable phosphoketolase / 0.675
2c42 TPPPyruvate synthase / 0.671
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.668
2c3u 2TPPyruvate synthase / 0.664
2c3o TPPPyruvate synthase / 0.663
2r8p T6FTransketolase 1 / 0.662
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.661
4qpz TPPBenzaldehyde lyase / 0.661
3upt TPPTransketolase / 0.659
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.658
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.658
2ag1 TPPBenzaldehyde lyase / 0.657
1tkb N1TTransketolase 1 2.2.1.1 0.655
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.654
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.654
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.652