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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mpe PV8 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 1.014
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.974
4mpc PV2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.949
4mp7 PFT[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.864
4egk RDCHeat shock protein HSP 90-alpha / 0.739
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.729
4bqj XKLHeat shock protein HSP 90-alpha / 0.726
4mp2 PV1[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.710
2yk2 YJWHeat shock protein HSP 90-alpha / 0.703
2yjw YJWHeat shock protein HSP 90-alpha / 0.689
1u0z RDCEndoplasmin / 0.683
3k99 PFTHeat shock protein HSP 90-alpha / 0.677
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.670
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1bgq RDCATP-dependent molecular chaperone HSP82 / 0.660
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.659
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4kip 1R9Mitogen-activated protein kinase 14 / 0.657
4e5f 0N7Polymerase acidic protein / 0.656
2wcg MT5Glucosylceramidase 3.2.1.45 0.654