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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mo2 FDA UDP-galactopyranose mutase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mo2 FDAUDP-galactopyranose mutase / 1.456
4mo2 FADUDP-galactopyranose mutase / 1.271
1i8t FADUDP-galactopyranose mutase 5.4.99.9 1.025
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.993
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.992
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.962
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.921
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.874
3he3 FADUDP-galactopyranose mutase / 0.870
3mj4 FADUDP-galactopyranose mutase / 0.852
2jae FADL-amino acid oxidase / 0.848
2hko FADLysine-specific histone demethylase 1A 1 0.825
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.804
1f8r FADL-amino-acid oxidase 1.4.3.2 0.797
2jb1 FADL-amino acid oxidase / 0.792
4guu FA9Lysine-specific histone demethylase 1B 1 0.790
1h83 FADPolyamine oxidase 1.5.3.14 0.788
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.787
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.782
2q7v FADThioredoxin reductase / 0.782
4jq9 FADDihydrolipoyl dehydrogenase / 0.782
4u8p FDAUDP-galactopyranose mutase / 0.776
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.774
2yg3 FADPutrescine oxidase / 0.773
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.770
2yg4 FADPutrescine oxidase / 0.770
4u8n FDAUDP-galactopyranose mutase / 0.770
3hdy FADUDP-galactopyranose mutase / 0.767
3qj4 FADRenalase / 0.767
4u8j FDAUDP-galactopyranose mutase / 0.765
3utf FDAUDP-galactopyranose mutase / 0.764
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.763
4gde FDAUDP-galactopyranose mutase / 0.763
4u8i FDAUDP-galactopyranose mutase / 0.762
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.760
2jb2 FADL-amino acid oxidase / 0.758
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.758
3kve FADL-amino-acid oxidase / 0.758
2eq6 FADDihydrolipoyl dehydrogenase / 0.755
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.753
4u8l FDAUDP-galactopyranose mutase / 0.751
2e1m FADL-glutamate oxidase / 0.749
4u8k FDAUDP-galactopyranose mutase / 0.749
3uth FDAUDP-galactopyranose mutase / 0.748
4i58 FADCyclohexylamine Oxidase / 0.748
4u8m FDAUDP-galactopyranose mutase / 0.748
3utg FDAUDP-galactopyranose mutase / 0.747
2xlr FADPutative flavin-containing monooxygenase / 0.746
3gyi FADCholesterol oxidase 1.1.3.6 0.745
4u2s FDACholesterol oxidase 1.1.3.6 0.745
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.745
2vvl FADMonoamine oxidase N 1.4.3.4 0.744
2xvf FADPutative flavin-containing monooxygenase / 0.744
4dsg FADUncharacterized protein / 0.744
2yg7 FADPutrescine oxidase / 0.743
3ukk FADUDP-galactopyranose mutase / 0.742
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
3cnj FADCholesterol oxidase 1.1.3.6 0.741
4u2l SFDCholesterol oxidase 1.1.3.6 0.740
4wx1 FDAUDP-galactopyranose mutase / 0.740
3bi2 FADPolyamine oxidase FMS1 / 0.739
4u8o FDAUDP-galactopyranose mutase / 0.739
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.738
1get FADGlutathione reductase 1.8.1.7 0.737
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.737
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.737
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.737
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.737
3we0 FADLysine 2-monooxygenase / 0.736
1b4v FADCholesterol oxidase 1.1.3.6 0.735
1nhr FADNADH peroxidase 1.11.1.1 0.735
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.735
1rsg FADPolyamine oxidase FMS1 / 0.733
4ech FADPolyamine oxidase FMS1 / 0.732
2ba9 FADPutative aminooxidase / 0.730
2dw4 FADLysine-specific histone demethylase 1A 1 0.730
2gew FADCholesterol oxidase 1.1.3.6 0.730
3gyj FADCholesterol oxidase 1.1.3.6 0.730
4rek FADCholesterol oxidase 1.1.3.6 0.730
4tlx FDAKtzI / 0.730
2xve FADPutative flavin-containing monooxygenase / 0.728
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.728
1ijh FADCholesterol oxidase 1.1.3.6 0.727
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.726
1n4v FADCholesterol oxidase 1.1.3.6 0.725
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.724
2bab FADPutative aminooxidase / 0.724
3uka FADUDP-galactopyranose mutase / 0.723
1f8s FADL-amino-acid oxidase 1.4.3.2 0.722
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.722
1nhs FADNADH peroxidase 1.11.1.1 0.722
5hhf FDAUDP-galactopyranose mutase / 0.722
4fwe FADLysine-specific histone demethylase 1B 1 0.721
2y48 FADLysine-specific histone demethylase 1A 1 0.719
1d7y FADFerredoxin reductase / 0.718
4xbf FADLysine-specific histone demethylase 1A 1 0.718
3cnt FADPolyamine oxidase FMS1 / 0.717
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.717
2eq9 FADDihydrolipoyl dehydrogenase / 0.716
4z24 FADPutative GMC-type oxidoreductase R135 1 0.716
1n4u FAECholesterol oxidase 1.1.3.6 0.715
2eq8 FADDihydrolipoyl dehydrogenase / 0.715
2gr3 FADFerredoxin reductase / 0.715
4u2t FADCholesterol oxidase 1.1.3.6 0.715
1cc2 FADCholesterol oxidase 1.1.3.6 0.714
3rha FDAPutrescine oxidase / 0.714
4dsh FDAUncharacterized protein / 0.714
1b8s FADCholesterol oxidase 1.1.3.6 0.713
3cox FADCholesterol oxidase 1.1.3.6 0.713
1n1p FADCholesterol oxidase 1.1.3.6 0.712
2xvh FADPutative flavin-containing monooxygenase / 0.712
4xwr FADCholesterol oxidase 1.1.3.6 0.712
4xxg FADCholesterol oxidase 1.1.3.6 0.712
1n4w FADCholesterol oxidase 1.1.3.6 0.710
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.710
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.710
3ish FADThioredoxin reductase 1.8.1.9 0.710
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.710
2qa1 FADPgaE / 0.709
2x8h FADThioredoxin glutathione reductase / 0.709
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.706
2b9x FADPutative aminooxidase / 0.706
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.706
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.706
1reo FADL-amino-acid oxidase 1.4.3.2 0.705
1ger FADGlutathione reductase 1.8.1.7 0.704
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.703
1npx FADNADH peroxidase 1.11.1.1 0.703
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.703
3zdn FADMonoamine oxidase N 1.4.3.4 0.703
2r9z FADGlutathione amide reductase / 0.702
3urh FADDihydrolipoyl dehydrogenase / 0.702
2gr0 FADFerredoxin reductase / 0.700
2xvi FADPutative flavin-containing monooxygenase / 0.700
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.699
2rab FADGlutathione amide reductase / 0.698
5br7 FADUDP-galactopyranose mutase / 0.698
3ka7 FADPutative oxidoreductase / 0.697
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.696
2b9y FADPutative aminooxidase / 0.696
2gvc FADThiol-specific monooxygenase 1.14.13 0.696
1mxt FAECholesterol oxidase 1.1.3.6 0.695
4cnk FADL-amino acid oxidase / 0.695
3b6d FAECholesterol oxidase 1.1.3.6 0.694
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.694
3ukl FADUDP-galactopyranose mutase / 0.694
4b64 FADL-ornithine N(5)-monooxygenase / 0.693
1nhq FADNADH peroxidase 1.11.1.1 0.692
2hqm FADGlutathione reductase 1.8.1.7 0.692
2yg6 FADPutrescine oxidase / 0.692
3mht SAHModification methylase HhaI 2.1.1.37 0.692
3ukk FDAUDP-galactopyranose mutase / 0.692
4yac NAIC alpha-dehydrogenase / 0.692
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.691
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.691
2iw5 FADLysine-specific histone demethylase 1A 1 0.691
4gdp FADPolyamine oxidase FMS1 / 0.691
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.691
1ges FADGlutathione reductase 1.8.1.7 0.690
1tdn FADL-amino-acid oxidase 1.4.3.2 0.690
4b69 FADL-ornithine N(5)-monooxygenase / 0.690
4fwj FADLysine-specific histone demethylase 1B 1 0.690
1cbo FADCholesterol oxidase 1.1.3.6 0.689
1f3p FADFerredoxin reductase / 0.688
3cty FADProbable thioredoxin reductase / 0.688
3icr FADCoenzyme A disulfide reductase / 0.688
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.688
4gur FADLysine-specific histone demethylase 1B 1 0.688
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.687
4gut FADLysine-specific histone demethylase 1B 1 0.687
4qi4 FADCellobiose dehydrogenase / 0.687
3ics FADCoenzyme A disulfide reductase / 0.686
3ukf FDAUDP-galactopyranose mutase / 0.685
4gus FADLysine-specific histone demethylase 1B 1 0.684
3ict FADCoenzyme A disulfide reductase / 0.683
1z6l FADPolyamine oxidase FMS1 / 0.682
3lov FADProtoporphyrinogen oxidase / 0.682
3r9u FADThioredoxin reductase / 0.682
4z26 FADPutative GMC-type oxidoreductase R135 1 0.682
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.680
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.680
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.679
3k4c FADPyranose 2-oxidase / 0.679
3nlc FADUncharacterized protein / 0.679
4tm4 FDAKtzI / 0.679
3kpf FADPolyamine oxidase 1.5.3.14 0.678
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.678
2bac FADPutative aminooxidase / 0.677
3pl8 FADPyranose 2-oxidase / 0.677
4eqw FADCoenzyme A disulfide reductase / 0.677
1pdh FASp-hydroxybenzoate hydroxylase / 0.676
1tdo FADL-amino-acid oxidase 1.4.3.2 0.676
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.676
1geu FADGlutathione reductase 1.8.1.7 0.675
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.674
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.674
2gv8 FADThiol-specific monooxygenase 1.14.13 0.674
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.674
1yqz FADCoenzyme A disulfide reductase / 0.673
2yg5 FADPutrescine oxidase / 0.673
3cge FADCoenzyme A disulfide reductase / 0.672
1fea FADTrypanothione reductase 1.8.1.12 0.671
3cnd FADPolyamine oxidase FMS1 / 0.671
4qi7 FADCellobiose dehydrogenase / 0.671
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.671
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.669
4em4 FADCoenzyme A disulfide reductase / 0.669
4eqx FADCoenzyme A disulfide reductase / 0.669
5l3d FADLysine-specific histone demethylase 1A 1 0.669
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.668
3cgc FADCoenzyme A disulfide reductase / 0.668
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.668
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.668
5je3 SAHMethyl transferase / 0.668
3sz0 FADSulfide-quinone reductase / 0.667
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.667
4tm0 FADKtzI / 0.667
4uir FADOleate hydratase 4.2.1.53 0.666
1d7l RFLp-hydroxybenzoate hydroxylase / 0.665
1feb FADTrypanothione reductase 1.8.1.12 0.665
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.665
1tyt FADTrypanothione reductase 1.8.1.12 0.665
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.665
4eqs FADCoenzyme A disulfide reductase / 0.665
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.665
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.664
2np7 NEAModification methylase TaqI 2.1.1.72 0.664
4em3 FADCoenzyme A disulfide reductase / 0.664
4emw FADCoenzyme A disulfide reductase / 0.664
4x4j FADPutative oxygenase / 0.664
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.663
4hsu FADLysine-specific histone demethylase 1B 1 0.663
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.662
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.662
4fwf FADLysine-specific histone demethylase 1B 1 0.662
5i39 FADL-amino acid deaminase / 0.662
3cn8 FADPolyamine oxidase FMS1 / 0.661
3t37 FADPyridoxine 4-oxidase / 0.661
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.661
4b63 FADL-ornithine N(5)-monooxygenase / 0.660
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
4rph FADUDP-galactopyranose mutase 5.4.99.9 0.660
2wba FADTrypanothione reductase 1.8.1.12 0.659
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.659
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
4b1b FADThioredoxin reductase 1.8.1.9 0.659
1tdk FADL-amino-acid oxidase 1.4.3.2 0.658
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.658
2c7q SAHModification methylase HhaI 2.1.1.37 0.658
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.658
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.658
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.658
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.658
4k2x FADPolyketide oxygenase/hydroxylase / 0.658
1y56 ATPUncharacterized protein / 0.657
2rgo FADAlpha-Glycerophosphate Oxidase / 0.657
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.657
3ept FDAPutative FAD-monooxygenase / 0.657
4ntd FADThioredoxin reductase / 0.657
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.657
2o07 MTASpermidine synthase 2.5.1.16 0.656
2uxx FAJLysine-specific histone demethylase 1A 1 0.656
2gqf FADUncharacterized protein HI_0933 / 0.655
2gr1 FADFerredoxin reductase / 0.655
2xdo FADTetX family tetracycline inactivation enzyme / 0.655
1f8w FADNADH peroxidase 1.11.1.1 0.654
3bg7 FADPyranose 2-oxidase / 0.654
3cgb FADCoenzyme A disulfide reductase / 0.654
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.654
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.653
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.652
3t2z FADSulfide-quinone reductase / 0.652
1bzl FADTrypanothione reductase 1.8.1.12 0.651
2wow FADTrypanothione reductase / 0.651
3atr FDAConserved Archaeal protein / 0.651
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.651
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
2npx FADNADH peroxidase 1.11.1.1 0.650
2tpr FADTrypanothione reductase 1.8.1.12 0.650
2yxl SFG450aa long hypothetical fmu protein / 0.650
3kpk FADSulfide-quinone reductase / 0.650
3lsm SFDPyranose 2-oxidase / 0.650
4ntc FADThioredoxin reductase gliT / 0.650