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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mht SAH Modification methylase HhaI 2.1.1.37

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mht SAHModification methylase HhaI 2.1.1.37 0.906
10mh SAHModification methylase HhaI 2.1.1.37 0.866
2zcj SAHModification methylase HhaI 2.1.1.37 0.863
2z6u SAHModification methylase HhaI 2.1.1.37 0.862
2c7q SAHModification methylase HhaI 2.1.1.37 0.861
1skm SAHModification methylase HhaI 2.1.1.37 0.844
3mht SAHModification methylase HhaI 2.1.1.37 0.844
2uyh SAHModification methylase HhaI 2.1.1.37 0.842
2i9k SAHModification methylase HhaI 2.1.1.37 0.829
1fjx SAHModification methylase HhaI 2.1.1.37 0.827
1mht SAHModification methylase HhaI 2.1.1.37 0.819
7mht SAHModification methylase HhaI 2.1.1.37 0.791
9mht SAHModification methylase HhaI 2.1.1.37 0.778
8mht SAHModification methylase HhaI 2.1.1.37 0.776
5mht SAHModification methylase HhaI 2.1.1.37 0.745
3qv2 SAH5-cytosine DNA methyltransferase / 0.738
4dkj SAHCytosine-specific methyltransferase / 0.723
3tm4 SAMUncharacterized protein / 0.722
4rtk SAHDNA adenine methylase 2.1.1.72 0.718
3swr SFGDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.716
3ldg SAHUncharacterized protein / 0.702
1nw5 SAMModification methylase RsrI 2.1.1.72 0.699
2g1p SAHDNA adenine methylase 2.1.1.72 0.698
2hmy SAMModification methylase HhaI 2.1.1.37 0.693
1yf3 SAHDNA adenine methylase / 0.684
3v97 SAHRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.682
3tlj SAHUncharacterized protein / 0.680
4nec SAHPutative SAM-dependent methyltransferase / 0.679
2zif SAMMethyltransferase / 0.678
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.674
2f8l SAMLmo1582 protein / 0.674
4rtm SAMDNA adenine methylase 2.1.1.72 0.673
4rtj SFGDNA adenine methylase 2.1.1.72 0.672
3pt6 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.671
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.669
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.665
2yx1 SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.664
2yxl SFG450aa long hypothetical fmu protein / 0.664
3pt9 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.664
4gbe SAHDNA adenine methylase 2.1.1.72 0.662
4rtl SFGDNA adenine methylase 2.1.1.72 0.662
1g60 SAMModification methylase MboII 2.1.1.72 0.660
5dst SAHProtein arginine N-methyltransferase 8 2.1.1 0.660
3tm5 SFGUncharacterized protein / 0.659
3axt SAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.658
4poo SAMPutative RNA methylase / 0.658
2dpm SAMModification methylase DpnIIA 2.1.1.72 0.657
4fzv SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.656
4rto SFGDNA adenine methylase 2.1.1.72 0.656
2bh2 SAH23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD / 0.655
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.655