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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mdh NAD Malate dehydrogenase, cytoplasmic 1.1.1.37

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 1.129
1b8v NADMalate dehydrogenase / 0.807
1bmd NADMalate dehydrogenase / 0.801
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.792
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.792
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.789
4i1i NADMalate dehydrogenase / 0.783
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.779
1ie3 NADMalate dehydrogenase / 0.777
1b8u NADMalate dehydrogenase / 0.768
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.767
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.766
1wze NADMalate dehydrogenase / 0.763
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.753
1pzh NADLactate dehydrogenase / 0.751
4ros APRMalate dehydrogenase / 0.750
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.749
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.748
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.746
5a1t NAIL-lactate dehydrogenase / 0.744
1gv0 NADMalate dehydrogenase / 0.743
1sow NADL-lactate dehydrogenase 1.1.1.27 0.742
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.740
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.740
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.739
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.738
1bdm NAXMalate dehydrogenase / 0.737
1ib6 NADMalate dehydrogenase / 0.730
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.730
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.730
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.727
1wzi NDPMalate dehydrogenase / 0.726
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.725
2aa3 AP0L-lactate dehydrogenase / 0.721
2x0r NADMalate dehydrogenase / 0.720
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.720
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.720
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.719
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.717
1pzf A3DLactate dehydrogenase / 0.717
1pzg A3DLactate dehydrogenase / 0.717
2a92 NAIL-lactate dehydrogenase / 0.717
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.716
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.715
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.713
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.713
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.712
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.711
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.710
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.710
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.709
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.709
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.709
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.707
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.705
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.704
1o6z NADMalate dehydrogenase / 0.704
1yqd NAPSinapyl alcohol dehydrogenase / 0.704
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.704
1uxj NADMalate dehydrogenase / 0.703
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.702
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.701
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.700
1uxk NADMalate dehydrogenase / 0.700
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.700
4j43 NADUncharacterized protein / 0.699
4rqu NADAlcohol dehydrogenase class-P / 0.699
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.698
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
3gvh NADMalate dehydrogenase / 0.695
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.695
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.693
2x0i NAIMalate dehydrogenase / 0.693
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.693
1yqx NAPSinapyl alcohol dehydrogenase / 0.692
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.691
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.691
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.690
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.685
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.683
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.683
4jji NADAlcohol dehydrogenase class-3 / 0.683
4l0q NADAlcohol dehydrogenase class-3 / 0.683
4oaq NDPR-specific carbonyl reductase / 0.682
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.682
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.682
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.682
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.681
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.679
3uko NADAlcohol dehydrogenase class-3 / 0.678
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.676
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.676
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.675
3jv7 NADSecondary alcohol dehydrogenase / 0.673
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
2xaa NADSecondary alcohol dehydrogenase / 0.670
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.669
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.667
1x7d NADPutative ornithine cyclodeaminase / 0.667
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.666
2y05 NAPProstaglandin reductase 1 / 0.665
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.664
2d8a NADL-threonine 3-dehydrogenase / 0.662
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.661
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.660
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.658
1u7h NADPutative ornithine cyclodeaminase / 0.658
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.658
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.658
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.658
2dc1 NADProbable L-aspartate dehydrogenase / 0.657
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.656
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.656
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.655
4cpd NADAlcohol dehydrogenase / 0.655
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.654
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.653
3two NDPMannitol dehydrogenase / 0.651
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.650