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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mbl 26L Serine/threonine-protein kinase pim-1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mbl 26LSerine/threonine-protein kinase pim-1 2.7.11.1 1.030
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2c3i IYZSerine/threonine-protein kinase pim-1 2.7.11.1 0.737
3r02 UNMSerine/threonine-protein kinase pim-1 2.7.11.1 0.713
3r04 UNQSerine/threonine-protein kinase pim-1 2.7.11.1 0.707
3jy0 LYGSerine/threonine-protein kinase pim-1 2.7.11.1 0.686
2xj2 985Serine/threonine-protein kinase pim-1 2.7.11.1 0.682
3umw 596Serine/threonine-protein kinase pim-1 2.7.11.1 0.681
3wix LC3Induced myeloid leukemia cell differentiation protein Mcl-1 / 0.668
4e5f 0N7Polymerase acidic protein / 0.660
4n70 2HXSerine/threonine-protein kinase pim-1 2.7.11.1 0.655
1pmu 9HPMitogen-activated protein kinase 10 2.7.11.24 0.654
1rt5 UC2Gag-Pol polyprotein 2.7.7.49 0.653
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.653
3fz1 B98Cyclin-dependent kinase 2 2.7.11.22 0.653