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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m6p 20R Nicotinamide phosphoribosyltransferase 2.4.2.12

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m6p 20RNicotinamide phosphoribosyltransferase 2.4.2.12 0.961
4m6q 20TNicotinamide phosphoribosyltransferase 2.4.2.12 0.862
4lww LWWNicotinamide phosphoribosyltransferase 2.4.2.12 0.833
4lts LTSNicotinamide phosphoribosyltransferase 2.4.2.12 0.829
4lva 20MNicotinamide phosphoribosyltransferase 2.4.2.12 0.773
4o28 1QSNicotinamide phosphoribosyltransferase 2.4.2.12 0.769
4kfn 1QRNicotinamide phosphoribosyltransferase 2.4.2.12 0.751
4kfo 1QSNicotinamide phosphoribosyltransferase 2.4.2.12 0.748
4lvg 20ONicotinamide phosphoribosyltransferase 2.4.2.12 0.680
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1nmd ATPMajor actin / 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2d09 FLVBiflaviolin synthase CYP158A2 / 0.660
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.660
2oap ANPType II secretion system protein (GspE-2) / 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
2zs9 ADPPantothenate kinase 2.7.1.33 0.660
3cwq ADPParA family chromosome partitioning protein / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3f8r NAPNADH oxidase/thioredoxin reductase / 0.660
3fzf ATPHeat shock cognate 71 kDa protein / 0.660
3u9d ATPActin, alpha skeletal muscle / 0.660
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.660
3zzn ADPL-lactate dehydrogenase / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.660
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.660
4kfp 1R7Nicotinamide phosphoribosyltransferase 2.4.2.12 0.652